The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Gcn5-related N-acetyltransferase (GNAT)

This superfamily contains Gcn5-related N-acetyltransferases (GNAT) which catalyse the transfer of acetyl groups from a donor acetyl CoA to an acceptor primary amine from a wide range of substrates, including glucosamine 6-phosphate, aminoglycoside antibiotics, spermine, spermidine, and other small molecules. N-acetyltransferases are involved in the acetylation of histones at specific lysine residues, a process that is required for transcriptional activation and that has been implicated in chromatin assembly and DNA replication. Histone N-acetyltransferase (HAT) enzymes belong to this superfamily, as well as other acetyltransferases such as GNA1, PCAF (a human transcriptional coactivator, p300/CBP-associating factor PMID:10393169), SNAT (serotonin N-acetyltransferase) or AANAT (arylalkylamine N-acetyltransferase), which acetylates serotonin into a circadian neurohormone that may participate in light-dark rhythms, and human mood and behaviour.

The N-acetyltransferase domain folds around a central, mixed beta-sheet that is largely built up of antiparallel strands; the only exception is a structurally conserved four-residue-long parallel stretch. Usually there are 6 beta-strands comprising the domain structure.

Pfam clan [PfamClan:CL0257], family PFAM:PF00583, INTERPRO:IPR000182, INTERPRO:IPR016181,PMID:15581578,PMID:24003232,DOI:10.1016/j.abb.2004.09.003

GO Diversity

Unique GO annotations
694 Unique GO terms

EC Diversity

Unique EC annotations
56 Unique EC terms

Species Diversity

Unique species annotations
24909 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1275
Domain clusters (>95% seq id): 261
Domain clusters (>35% seq id): 188
Unique PDBs: 494
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 699
Function
Unique EC: 56
Unique GO: 694
Taxonomy
Unique Species: 24909