The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
88789
72287
3D
1jmvA00 - 91.0
88283
30438
EC
3D
1b6tA00 - 92.8
88849
25167
EC
3D
2derA01 - 93.8
86425
24037
EC
3D
1ffyA01 - 86.5
61883
22873 - - 5.3
18900
20236
EC
3D
1li5A01 - 83.3
86637
19969
EC
3D
3zgzA01 - 93.8
89013
19413
EC
3D
2vxoA02 - 94.2
88792
19287
EC
3D
2pidA01 - 95.3
88968
18565
EC
3D
2oq2A00 - 97.0
86499
18449
EC
3D
1f4lA02 - 93.5
87752
18361
EC
3D
3al0C02 - 94.9
52835
17977 - - 37.1
89155
3 +
17644
EC
3D
1wxeA00 - 90.1
86689
17641
EC
3D
3sp1A01 - 83.9
86404
16373
EC
- - 92.6
89128
16225
EC
3D
3op1A01 - 91.8
89071
15187
EC
3D
1k4kA00 - 90.6
87825
15163
EC
3D
1tfuA00 - 97.0
89168
14505
EC
3D
1ct9A02 - 91.2
87614
14386
EC
3D
3sz3A01 - 93.3
88707
14003
EC
3D
1ihoA01 - 95.1
87272
13011
EC
3D
1bs2A01 - 86.9
89154
11769
EC
3D
3bl5A00 - 92.0
88446
Ile
11704
EC
3D
1ni5A01 - 89.3
89046
11490
EC
3D
3elbA01 - 88.8
87494
11228
EC
- - 91.1
88842
10171
EC
3D
2nz2A01 - 96.8
88701
9833
EC
3D
4h3sA01 - 94.8
43899
9744
EC
- - 32.4
88798
8761
EC
3D
4kr6A02 - 97.4
89050
Asp
8552
EC
3D
1nzjA01 - 89.6
86612
8190
EC
3D
1ileA01 - 90.5
87620
7378
EC
3D
5tgtA01 - 94.0
49058
6836
EC
3D
3fdxA00 - 72.1
85808
6008 - - 84.3
85169
5736
EC
- - 86.3
84767
5605 - - 23.5
86526
5587
EC
- - 87.1
88425
5284
EC
3D
1x6vA03 - 96.5
89152
5201
EC
- - 79.7
88597
4390
EC
- - 91.2
52308
4292
EC
3D
4qrdA01 - 96.3
86196
4192
3D
1efvB00 - 89.1
86531
3993
EC
3D
3c8zA01 - 85.3
72667
3975 - - 2.4
85893
3921 - - 56.7
87948
3626
EC
3D
2a1tR01 - 90.9
88721
3323
EC
3D
1irxA01 - 95.0
87801
3315
EC
3D
3nd5A00 - 92.1
87481
3259
EC
3D
3fnrA02 - 93.2
14575
2919 - - 18.6
88846
Photoreactivation
2880
EC
3D
1dnpA01 - 96.4
89137
2732 - - 77.2
88403
2520
EC
3D
1o5tA01 - 80.5
86600
2393
EC
- - 84.2
84131
2224
EC
3D
1wkbA01 - 84.6
88725
2177
EC
3D
1n3lA01 - 90.7
89191
2056
EC
- - 97.5
87428
1935
EC
3D
4zcpA00 - 84.7
88437
1934
EC
3D
1gzuA00 - 83.7
88347
1923
EC
- - 94.3
88601
1919
EC
- - 87.3
87579
Ile
1837
EC
- - 93.7
87735
1641
EC
- - 93.4
89224
AFU_orthologue AFUA_6G11040
1548
EC
3D
2wsiA00 - 77.5
88713
1501
EC
- - 97.6
87828
1185
EC
- - 93.0
89108
1009
EC
3D
1ej2A00 - 98.7
88982
Ile
990
EC
3D
1wy5A01 - 92.8
89105
980
EC
- - 86.7
86791
950
EC
- - 85.1
86260
895
EC
- - 25.7
89064
Ile
892
EC
- - 95.3
89038
Gln
848
EC
- - 92.5
85035
757
EC
- - 62.8
83114
678 - - 25.8
86361
Photolyase-like
565
EC
3D
4ct0A01 - 93.3
87378
545
EC
- - 90.1
32357
Ile
534
EC
- - 6.2
88628
528
EC
- - 86.3
38005
497
EC
- - 67.5
88973
483
EC
- - 92.7
89238
472
EC
- - 95.7
89027
462 - - 92.7
88814
461
EC
- - 96.6
89032
460
EC
- - 81.6
86009
457
EC
3D
1cozA00 - 41.0
81269
455
EC
- - 91.3
88529
423
EC
- - 81.7
88617
421
EC
- - 92.1
44338
404 - - 12.8
87248
400 - - 88.2
88774
389
EC
- - 90.7
45733
383
EC
- - 48.6
87002
346 - - 94.8
56679
332
3D
1tq8A00 - 20.6
88939
330
EC
3D
2ijgX01 - 92.1
88451
Ile
312
EC
- - 90.0
86049
304
EC
- - 69.0
87802
288
EC
- - 93.1
83586
278
EC
- - 54.3
89048
261 - - 88.7
85763
260
EC
- - 84.0
87746
251
EC
- - 89.4
86735
244
EC
- - 50.2
87558
240 - - 96.1
88449
239
EC
3D
1vlhA00 - 94.2
87455
217 - - 92.6
89010
187
EC
- - 94.8
43558
180
EC
3D
1lw7A01 - 63.3
89087
179 - - 91.3
84837
159
EC
- - 17.5
88992
158
EC
3D
3do8A00 - 91.0
88678
150
EC
- - 89.7
51151
145 - - 0.8
48391
143
EC
- - 32.5
48961
142
EC
- - 4.4
88726
140
EC
- - 88.1
87989
134
EC
- - 86.8
89121
131
EC
- - 92.3
86627
131
EC
3D
1qu3A01 - 65.1
84605
130 - - 11.0
61993
121
EC
- - 18.0
89149
Asp
120
EC
- - 95.7
80071
118
EC
- - 11.1
87809
115
EC
- - 91.1
86030
115
EC
- - 13.2
88706
114
EC
- - 85.6
47253
114
EC
- - 21.2
86154
113
EC
- - 75.0
49873
112
EC
- - 16.3
27620
Ile
110
EC
- - 9.8
87083
110
EC
3D
5ekdA01 - 73.2
71105
105
EC
- - 17.4
88551
102
EC
- - 93.2
85801
100
EC
- - 73.4
42931
88
EC
- - 13.2
52135
85
EC
- - 30.3
89166
Ile
78
EC
- - 93.7
10847
77
EC
- - 29.4
88152
Ile
77
EC
- - 78.6
88289
74
EC
- - 89.5
86094
74
EC
- - 55.0
84569
Ile
72
EC
- - 46.4
86269
69
EC
- - 14.6
87791
68
EC
- - 54.3
34875
67
EC
- - 0.0
88513
65
EC
- - 86.9
89103
61
EC
- - 76.2
28335
Ile
60
EC
- - 4.4
87255
60
EC
- - 67.6
77553
59 - - 17.5
26868
Ile
56
EC
- - 11.0
87520
52
EC
- - 88.4
88350
49
EC
3D
3umvA01 - 76.4
85193
48
EC
- - 22.1
64671
47
EC
- - 33.6
48404
44
EC
- - 3.0
88684
43
EC
- - 92.2
89143
43
EC
- - 88.9
86343
43
EC
- - 59.7
89201
42 - - 94.3
40121
41 - - 1.7
47356
40
EC
- - 7.1
67090
38
EC
- - 0.0
29343
Ile
37
EC
- - 0.6
87135
37
EC
- - 50.6
25564
Ile
37
EC
- - 3.0
37439
Ile
36
EC
- - 19.6
28171
36
EC
- - 0.0
9043
32
EC
- - 3.2
84975
30
EC
- - 18.8
89156
27
EC
- - 71.6
87749
26
EC
- - 67.8
88001
Glutamate--tRNA ligase GluRS
26
EC
- - 45.0
65638
25 - - 0.0
89035
25
EC
- - 81.0
39192
25 - - 0.0
88742
24
EC
- - 82.7
84867
24
EC
- - 12.9
47213
24
3D
1efvA02 - 48.8
48423
24
EC
- - 21.5
84873
24 - - 28.8
53598
23
EC
- - 1.5
88010
22 - - 51.5
38815
22 - - 14.0
89056
21
EC
- - 31.6
86233
20
EC
- - 57.8
86137
19
EC
- - 39.1
63045
19
EC
- - 11.5
71945
18
EC
- - 2.7
84833
18 - - 24.6
84794
Ile
18
EC
- - 22.2
46561
18
EC
- - 16.9
84553
17 - - 50.5
88366
17
EC
- - 62.3
89139
17
EC
- - 0.0
13670
16 - - 0.0
86569
16
EC
3D
1pg0A01 - 72.7
88978
15
EC
- - 68.9
65648
15
EC
- - 3.5
47327
13
EC
- - 16.2
60255
13 - - 18.6
63037
13 - - 28.6
85930
12 - - 37.7
89131
Asp
12 - - 16.4
86252
11
EC
- - 36.4
84698
11 - - 28.2
21222
11
EC
- - 5.8
84961
Ile
11
EC
- - 29.3
85588
10
EC
- - 21.2
85746
10 - - 20.1
59449
10
EC
- - 28.8
88125
10 - - 28.1
45333
10 - - 12.9
88439
10
EC
- - 33.4
45357
6-4
10
EC
- - 16.3
49737
10 - - 15.8
42877
Ile
9
EC
- - 0.0
41116
Ile
9
EC
- - 3.0
16782
9
EC
- - 17.9
88599
Gln
9
EC
- - 62.8
10335
9
EC
- - 0.0
89198
8
EC
- - 58.1
65640
8 - - 1.9
51973
8 - - 10.1
46572
8
EC
- - 7.9
88685
8
EC
- - 71.2
31122
8 - - 29.5
89135
7
EC
- - 49.6
63647
7 - - 16.9
87446
7
EC
- - 14.5
88371
7
EC
- - 13.8
63483
7
EC
- - 19.4
52780
7
3D
1np7A01 - 3.2
88918
7
EC
- - 28.2
39374
6 - - 2.1
32510
6 - - 3.0
49879
6
EC
- - 27.2
47954
6
EC
- - 3.9
35824
6 - - 14.8
88959
Asp
6 - - 54.9
51567
6
EC
- - 11.5
52330
6 - - 11.2
48426
6
EC
- - 2.8
45104
6
EC
- - 5.5
87459
6
EC
- - 62.3
88611
6
EC
- - 48.1
3802
5
EC
- - 26.6
47462
5 - - 14.3
88191
Ile
5
EC
- - 44.2
52010
5 - - 9.1
76419
5
EC
- - 19.0
89074
5 - - 69.9
47322
5 - - 3.3
88905
5
EC
- - 29.9
85975
5
EC
- - 11.2
32362
Ile
4
EC
- - 10.7
37159
Ile
4
EC
- - 0.0
89031
4
EC
- - 51.9
88607
4
EC
- - 43.7
49855
4
EC
- - 0.0
52777
4 - - 0.0
88386
4
EC
- - 33.4
85795
Ile
4
EC
- - 23.5
63321
3 - - 9.5
45332
3 - - 17.5
88626
3
EC
- - 24.8
87174
3 - - 23.2
46937
3
3D
1mjhA00 - 0.0
86042
3
EC
- - 12.1
43207
3 - - 6.0
86047
3
EC
- - 0.0
12826
Glutamine-hydrolyzing
3
EC
- - 26.5
35893
3
EC
- - 9.9
54757
3 - - 4.0
87077
3
EC
- - 21.0
45140
3 - - 10.2
52783
3
EC
- - 3.6
88777
3
EC
- - 67.4
53117
3 - - 0.0
45069
3
EC
- - 6.1
48934
6-4
3
EC
- - 4.6
88829
Ile
2
EC
- - 37.3
62440
2 - - 1.4
40503
2
EC
- - 7.1
60333
2 - - 4.2
87078
2
EC
- - 22.8
47397
2 - - 7.3
88036
2
EC
- - 38.1
28751
2
EC
- - 8.3
56669
2
EC
- - 0.0
17303
2
EC
- - 6.7
62885
2 - - 11.0
39598
Ile
2
EC
- - 5.5
88884
Ile
2
EC
- - 37.3
54204
2
EC
- - 2.6
32638
AFU_orthologue AFUA_4G05940
2 - - 0.0
44869
2 - - 2.1
42547
2
EC
- - 4.5
85647
2
EC
- - 20.8
13452
2 - - 8.0
70231
2
EC
- - 0.0
29142
1 - - 0.0
88750
1
EC
- - 0.0
55549
1 - - 0.0
80727
Ile
1
EC
- - 0.0
88109
1
EC
- - 0.0
36765
1 - - 0.0
85920
1
EC
- - 0.0
66143
1 - - 0.0
50446
1 - - 0.0
57791
1 - - 0.0
61734
1
EC
- - 0.0
52405
1 - - 0.0
61737
1 - - 0.0
54053
1 - - 0.0
12846
1 - - 0.0
52772
1
EC
- - 0.0
51142
1 - - 0.0
61732
1
EC
- - 0.0
51578
1
EC
- - 0.0
46159
1 - - 0.0
88141
1
EC
- - 0.0
65643
1 - - 0.0
59374
1 - - 0.0
52478
Tyrosine--tRNA ligase Tyrrs AFU_orthologue AFUA_4G08320
1
EC
- - 0.0
50296
1
EC
- - 0.0
61019
1
EC
- - 0.0
36760
Ile
1
EC
- - 0.0
60231
1 - - 0.0
88204
1
EC
- - 0.0
52776
1 - -
79310
1 - - 0.0
17407
1
EC
- - 0.0
88392
1
EC
- - 0.0
22680
Ile
1
EC
- - 0.0
17740
1
EC
- - 0.0
18095
Ile
1
EC
- - 0.0
27180
1 - - 0.0
89141
- -
87918
- -
88216
- -
80441
- -