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CATH Superfamily 3.40.50.1480

Adenosylhomocysteinase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Adenosylhomocysteinase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Adenosylhomocysteinase-like

Structural domains comprising this superfamily share the structure of the enzyme adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, AdoHcyase), which is formed in methylation and catalyses the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and a key regulatior of the intracellular concentration of adenosylhomocysteine. In addition, this enzyme is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, and thus plays a critical role in the modulation of their activity PMID:9586999,PMID:16061414,PMID:11325033,PMID:15165742.

GO Diversity

Unique GO annotations
64 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
9364 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 181
Domain clusters (>95% seq id): 15
Domain clusters (>35% seq id): 3
Unique PDBs: 49
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 32
Function
Unique EC: 1
Unique GO: 64
Taxonomy
Unique Species: 9364
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