The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1919 - - 96.6
2
1690 - - 81.9
3
1677
3D
1rkqB01 - 98.1
5
1548
3D
5xabA03 - 81.8
4
1533
3D
4retC03 - 87.5
6
1301 - - 97.4
7
1269 - - 61.3
8
1186 - - 88.5
9
813 - - 88.6
10
788 - - 77.3
11
754 - - 77.3
13
683
3D
6du3B00 - 75.5
12
657 - - 78.4
14
645 - - 86.6
15
625 - - 89.2
16
576
3D
2c4nA02 - 78.4
29
504
3D
4hgrH00 - 97.4
17
489 - - 83.4
18
486 - - 81.8
19
445
3D
4qqfF00 - 93.0
20
443
3D
2yj6B01 - 87.4
22
434
3D
2yy6B01 - 90.9
21
423 - - 89.4
23
408 - - 89.7
24
402 - - 92.9
25
382
3D
3fvvB01 - 91.8
26
377 - - 80.6
27
364 - - 68.8
28
346 - - 94.7
30
323
3D
2c4nA01 - 49.0
31
312 - - 89.9
32
304
3D
2vkqA01 - 81.2
33
277
3D
2qltA01 - 85.5
34
275 - - 75.5
35
273 - - 76.6
36
260
3D
4uavA01 - 95.8
37
259
3D
3l8gA00 - 90.6
38
241 - - 89.9
41
237
3D
5t41A03 - 78.0
49
235
3D
3cz4A00 - 24.0
39
232 - - 94.3
40
229 - - 73.5
46
227
3D
6cfvA01 - 78.7
42
227 - - 23.9
43
224 - - 70.3
44
223 - - 71.9
45
220 - - 88.3
53
206
3D
3pdwA02 - 95.2
47
206 - - 83.2
48
200
3D
3n28A01 - 72.3
50
194
3D
3shqA02 - 76.9
51
190
3D
2x4dB02 - 94.5
52
187 - - 89.1
54
181 - - 94.4
55
177
3D
3l5kA01 - 84.9
57
177
3D
3a1eB01 - 91.4
59
177
3D
3pdwA01 - 76.8
61
172
3D
2fpxB00 - 84.6
56
172 - - 88.4
58
169
3D
2b0cA01 - 29.8
60
168
3D
3hltC02 - 84.6
107
166
3D
6aumA01 - 62.2
72
165
3D
2iohD01 - 87.1
66
159
3D
3f9rB01 - 88.4
62
158 - - 63.1
65
156
3D
3rf6B01 - 87.4
63
153 - - 71.2
64
152 - - 24.4
67
148 - - 81.1
68
147 - - 91.1
69
146 - - 94.4
70
145 - - 0.0
71
143 - - 77.4
73
140 - - 85.3
77
139
3D
1nnlB01 - 93.4
74
136 - - 77.7
75
136 - - 81.7
79
135
3D
2g80D01 - 83.5
76
133 - - 70.7
78
132 - - 93.0
80
127 - - 83.5
82
119
3D
3ewiB00 - 95.8
81
118 - - 84.0
83
117 - - 90.3
84
116 - - 88.2
85
113 - - 47.8
86
111 - - 93.9
87
107 - - 70.4
90
102
3D
3mmzD00 - 47.0
88
101 - - 72.9
89
100 - - 72.1
91
98 - - 20.4
92
97 - - 60.5
93
97 - - 96.1
106
95
3D
4g9bA01 - 80.9
94
94 - - 84.2
95
92 - - 76.8
96
90 - - 77.8
97
87 - - 70.3
98
86 - - 81.8
99
85 - - 73.3
100
84 - - 75.5
102
83
3D
1zs9A01 - 68.7
101
81 - - 88.6
133
5'
3'
81
3D
2jarA01 - 69.6
105
75
3D
1rkvB01 - 30.9
103
75 - - 9.5
104
74 - - 82.0
108
68 - - 67.2
116
67
3D
4knwC01 - 49.7
109
66 - - 56.1
111
65 - - 70.9
110
65 - - 49.1
112
64 - - 73.0
113
64 - - 73.1
115
64 - - 91.6
118
64
3D
2x4dB01 - 78.3
114
64 - - 72.6
117
63 - - 77.8
119
62 - - 85.6
120
61 - - 81.0
123
60
3D
4bkmD02 - 76.4
121
59 - - 89.8
122
59 - - 72.6
168
57
3D
3l8hD00 - 85.3
127
56
3D
1u7pD00 - 81.8
124
55 - - 82.2
125
53 - - 75.5
126
51 - - 80.1
128
50 - - 73.1
129
50 - - 79.6
130
50 - - 84.1
140
50
3D
5aesB02 - 78.4
132
49 - - 65.4
131
49 - - 85.2
163
49
3D
4bkmD01 - 64.3
135
46 - - 80.0
134
46 - - 82.4
136
45 - - 70.1
137
45 - - 72.4
138
45 - - 77.6
139
43 - - 27.3
141
43 - - 14.2
142
41 - - 74.7
146
40
3D
4ezeB00 - 5.0
143
40 - - 85.1
145
39 - - 89.3
144
39 - - 86.7
147
38 - - 74.4
148
37 - - 71.1
149
36 - - 76.3
152
36 - - 88.4
151
36 - - 79.8
150
36 - - 70.3
153
35 - - 74.5
154
35 - - 82.4
155
34 - - 80.1
156
34 - - 88.0
160
33
3D
3qucA01 - 25.7
158
32 - - 73.0
157
32 - - 16.1
159
32 - - 92.5
178
31
3D
3rf6B02 - 75.5
161
31 - - 51.5
162
31 - - 67.2
164
30 - - 71.8
231
30
3D
2ia5L02 - 21.8
170
29 - - 98.4
165
29 - - 87.4
167
29 - - 74.6
169
29 - - 96.7
166
29 - - 81.8
182
28
3D
3skyA01 - 77.5
173
28 - - 77.4
171
28 - - 72.3
172
28 - - 73.2
175
27 - - 72.5
174
27 - - 2.0
179
27 - - 87.2
177
27 - - 91.1
176
27 - - 73.0
180
26 - - 48.7
184
26 - - 97.5
181
26 - - 14.5
188
26
3D
5e0oA02 - 73.9
183
26 - - 87.6
185
25 - - 84.6
187
24 - - 33.8
195
24
3D
3opxA01 - 55.6
186
+2
24 - - 84.1
191
23 - - 82.9
212
23
3D
4i9gB01 - 71.7
192
23 - - 81.7
193
23 - - 91.3
189
23 - - 78.8
190
23 - - 84.1
194
22 - - 75.2
198
21 - - 87.5
196
21 - - 8.0
197
21 - - 2.5
223
21
3D
4navD00 - 9.4
202
20 - - 15.2
200
20 - - 85.2
199
20 - - 57.1
203
20 - - 87.5
204
20 - - 74.6
201
20 - - 31.2
216
20
3D
2q4rA01 - 34.3
207
19 - - 77.1
209
19 - - 4.2
210
19 - - 71.9
211
19 - - 63.5
205
19 - - 36.4
206
19 - - 41.0
208
19 - - 26.1
217
18 - - 2.0
213
18 - - 19.2
224
18
3D
2fi1A01 - 17.4
218
18 - - 11.6
221
18 - - 58.8
214
18 - - 16.4
219
18 - - 71.6
220
18 - - 3.1
215
18 - - 61.3
262
17
3D
2msnA01 - 23.1
225
17 - - 52.3
222
17 - - 0.0
226
17 - - 5.6
232
16 - - 12.8
229
16 - - 3.4
233
16 - - 6.8
228
16 - - 81.9
234
16 - - 1.7
227
16 - - 41.0
230
16 - - 32.3
235
HAD
16 - - 77.5
266
16
3D
4i9gB02 - 14.7
238
15 - - 14.2
236
15 - - 78.5
240
HAD superfamily
15 - - 3.6
239
15 - - 73.7
237
15 - - 42.6
246
14 - - 4.3
247
14 - - 1.5
242
14 - - 78.8
243
14 - - 73.5
248
14 - - 0.0
250
14 - - 29.4
249
14 - - 13.3
244
14 - - 7.7
245
14 - - 61.0
241
14 - - 31.6
252
13 - - 10.7
254
13 - - 74.1
253
13 - - 19.8
255
13 - - 65.2
251
13 - - 44.8
257
HAD
12 - - 87.2
263
12 - - 48.0
267
12 - - 82.9
273
12
3D
2ah5A01 - 15.2
268
12 - - 69.3
258
12 - - 40.9
260
12 - - 0.9
264
12 - - 20.3
259
12 - - 9.7
265
12 - - 39.9
256
12 - - 21.8
261
12 - - 20.3
272
11 - - 32.6
278
11 - - 11.8
281
11 - - 67.0
271
11 - - 2.6
279
11 - - 68.4
280
11 - - 99.4
274
11 - - 86.4
276
11 - - 0.0
269
11 - - 32.3
275
11 - - 10.6
270
11 - - 61.1
277
11 - - 22.5
285
10 - - 0.0
308
10
3D
3ef0A01 - 50.3
301
10 - - 61.8
294
10 - - 47.5
299
10 - - 77.0
284
10 - - 72.1
289
10 - - 40.7
290
10 - - 20.7
293
10 - - 10.2
302
10 - - 31.2
362
10
3D
2i34B00 - 11.2
298
10 - - 72.5
288
10 - - 9.3
287
10 - - 72.1
297
10 - - 17.9
283
10 - - 31.1
295
10 - - 69.3
300
10 - - 49.4
286
10 - - 14.8
296
10 - - 19.5
292
10 - - 23.3
291
10 - - 0.0
282
10 - - 21.4
311
9 - - 0.0
307
9 - - 71.4
305
9 - - 0.7
309
9 - - 75.4
310
9 - - 75.2
303
9 - - 37.4
313
9 - - 60.9
312
9 - - 63.8
304
9 - - 0.0
306
9 - - 0.0
323
8 - - 14.7
330
8 - - 5.9
326
8 - - 28.3
315
8 - - 36.4
317
8 - - 8.1
319
8 - - 4.3
329
8 - - 9.5
322
8 - - 1.1
316
8 - - 0.6
314
8 - - 74.7
334
8 - - 70.8
318
8 - - 15.1
325
8 - - 40.2
333
8 - - 78.1
320
8 - - 0.9
328
8 - - 23.4
331
8 - - 36.8
324
8 - - 76.5
332
8 - - 32.6
327
8 - - 18.5
321
5-phospho-D-ribitylamino
8 - - 7.9
350
7 - - 27.0
340
7 - - 5.3
349
7 - - 7.3
359
7 - - 51.1
360
7 - - 64.0
353
7 - - 14.9
335
7 - - 74.7
344
7 - - 16.2
336
7 - - 13.7
351
7 - - 57.1
342
7 - - 22.3
341
7 - - 3.0
346
7 - - 8.2
354
7 - - 4.2
355
7 - - 1.4
339
HAD
7 - - 82.9
345
7 - - 8.8
356
7 - - 7.8
337
7 - - 5.5
347
7 - - 2.8
338
7 - - 54.0
516
7
3D
5ksdB03 - 31.1
357
7 - - 89.4
358
7 - - 41.5
348
7 - - 0.0
352
7 - - 15.2
343
7 - - 0.0
366
6 - - 6.9
375
6 - - 9.9
361
6 - - 86.0
365
6 - - 7.5
367
6 - - 9.8
372
6 - - 18.3
376
6 - - 5.9
371
6 - - 45.9
378
6 - - 64.7
381
6 - - 60.8
373
6 - - 10.2
377
HAD superfamily
6 - - 5.0
363
6 - - 2.5
364
6 - - 16.0
379
6 - - 0.0
452
6
3D
3hltC01 - 25.5
370
6 - - 33.8
380
6 - - 29.0
369
6 - - 14.0
368
6 - - 50.4
374
6 - - 7.6
391
5 - - 6.1
387
5 - - 77.7
395
5 - - 16.1
383
5 - - 0.0
382
5 - - 9.1
405
5 - - 51.2
392
5 - - 0.0
399
5 - - 15.1
386
5 - - 39.6
402
5 - - 0.0
396
5 - - 15.0
389
5 - - 44.3
400
5 - - 9.2
393
5 - - 4.1
385
5 - - 60.1
397
5 - - 12.8
401
5 - - 0.0
404
5 - - 65.4
390
SerB
5 - - 93.9
388
5 - - 42.2
394
5 - - 9.1
398
5 - - 11.7
384
5 - - 55.0
403
5 - - 6.8
444
4 - - 43.0
456
4 - - 71.2
413
4 - - 3.1
432
4 - - 7.0
449
4 - - 73.3
425
4 - - 46.9
412
4 - - 88.2
440
4 - - 63.1
457
4 - - 63.4
419
4 - - 15.7
406
4 - - 0.0
421
4 - - 14.3
408
4 - - 77.9
443
4 - - 47.3
431
4 - - 0.0
453
4 - - 69.9
436
4 - - 2.1
427
4 - - 15.9
426
4 - - 9.1
414
4 - - 5.6
423
4 - - 17.6
422
4 - - 0.0
439
4 - - 12.3
407
4 - - 39.5
435
4 - - 35.4
448
4 - - 36.8
450
4 - - 43.2
451
4 - - 61.5
454
4 - - 72.2
410
4 - - 45.7
430
4 - - 14.6
447
4 - - 56.0
415
4 - - 7.5
438
4 - - 13.0
417
4 - - 0.0
446
4 - - 82.4
424
4 - - 60.0
434
4 - - 29.2
442
4 - - 1.1
455
4 - - 85.0
437
4 - - 4.8
418
4 - - 7.3
416
4 - - 15.1
445
4 - - 74.6
441
4 - - 68.9
428
4 - - 11.1
429
4 - - 9.3
409
4 - - 62.9
433
4 - - 39.6
411
4 - - 78.0
420
4 - - 14.2
512
3 - - 52.7
463
3 - - 40.1
517
3 - - 66.8
458
3 - - 20.2
495
3 - - 1.4
486
3 - - 2.5
508
3 - - 69.0
506
3 - - 4.6
468
3 - - 8.4
477
3 - - 0.0
501
3 - - 2.8
490
3 - - 23.6
461
3 - - 52.5
520
3 - - 45.6
467
SerB
3 - - 0.0
481
3 - - 5.4
474
3 - - 9.5
472
3 - - 7.0
505
3 - - 7.3
491
3 - - 39.5
509
3 - - 82.4
488
3 - - 0.0
507
3 - - 20.3
498
+
3 - - 13.2
483
3 - - 2.6
462
3 - - 57.8
476
3 - - 8.8
469
3 - - 5.4
511
3 - - 3.9
471
3 - - 3.5
502
3 - - 11.4
464
3 - - 38.5
494
3 - - 0.0
487
3 - - 1.6
482
3 - - 32.8
499
3 - - 0.0
473
3 - - 9.2
480
3 - - 0.0
493
3 - - 7.1
475
3 - - 75.4
515
3 - - 62.4
519
P-type
3 - - 66.3
510
3 - - 30.1
465
3 - - 13.8
479
3 - - 4.1
503
3 - - 0.8
484
3 - - 0.0
522
3 - - 77.6
459
3 - - 37.7
470
3 - - 6.2
485
3 - - 6.2
460
3 - - 19.6
496
3 - - 1.5
500
3 - - 6.6
514
3 - - 52.9
513
3 - - 64.8
492
3 - - 59.0
489
3 - - 3.3
521
3 - - 50.4
518
3 - - 42.5
497
3 - - 4.0
478
3 - - 12.2
504
3 - - 41.0
466
3 - - 77.5
569
2 - - 0.0
536
2 - - 19.4
558
2 - - 0.0
573
2 - - 4.3
638
2 - - 9.8
581
2 - - 0.0
652
2 - - 34.5
606
2 - - 0.0
545
2 - - 0.0
588
2 - - 40.8
542
2 - - 35.6
574
2 - - 6.2
566
2 - - 12.9
526
2 - - 1.4
604
2 - - 0.0
626
2 - - 0.0
539
2 - - 32.6
532
2 - - 19.8
584
2 - - 7.6
649
2 - - 31.0
648
2 - - 38.9
642
2 - - 0.6
554
2 - - 7.8
552
2 - - 0.0
563
2 - - 0.0
546
2 - - 3.3
537
2 - - 9.0
529
2 - - 0.0
636
2 - - 4.5
600
2 - - 1.9
625
2 - - 0.0
570
2 - - 0.0
655
2 - - 41.4
597
2 - - 8.8
559
2 - - 0.0
580
2 - - 10.2
653
2 - - 32.9
523
2 - - 0.0
595
2 - - 0.0
644
2 - - 5.5
568
2 - - 0.0
525
2 - - 0.0
650
2 - - 31.3
629
2 - - 0.0
533
2 - - 14.6
615
2 - - 34.1
635
2 - - 4.3
575
2 - - 11.3
543
2 - - 34.8
603
2 - - 0.0
565
2 - - 8.4
553
2 - - 0.0
555
2 - - 0.0
647
2 - - 31.4
593
2 - - 8.8
641
2 - - 0.0
616
2 - - 35.3
640
2 - - 0.0
562
2 - - 5.9
599
2 - - 0.0
609
2 - - 25.3
587
2 - - 11.6
624
2 - - 0.0
656
2 - - 39.6
596
2 - - 9.0
613
2 - - 25.3
547
2 - - 0.0
631
2 - - 1.0
528
2 - - 3.0
560
2 - - 0.0
634
2 - - 15.9
578
2 - - 4.1
540
2 - - 16.9
571
2 - - 40.3
594
2 - - 1.5
586
2 - - 13.2
534
2 - - 12.7
633
2 - - 1.6
646
2 - - 31.7
556
2 - - 4.5
549
2 - - 5.3
614
2 - - 33.6
583
2 - - 0.0
591
2 - - 0.0
619
2 - - 40.5
621
2 - - 11.4
524
2 - - 0.0
598
2 - - 5.1
602
2 - - 0.0
612
2 - - 22.8
564
2 - - 8.7
657
2 - - 42.2
576
2 - - 7.6
544
2 - - 4.6
623
2 - - 0.0
628
2 - - 0.0
630
2 - - 0.0
608
2 - - 18.3
561
2 - - 9.4
550
2 - - 0.0
592
2 - - 0.0
530
2 - - 0.0
654
2 - - 40.3
572
2 - - 5.4
527
2 - - 10.3
548
2 - - 0.0
627
2 - - 11.4
637
2 - - 21.5
579
2 - - 0.0
535
2 - - 11.7
541
2 - - 35.6
567
2 - - 0.0
605
2 - - 0.0
607
2 - - 0.0
582
2 - - 0.0
557
2 - - 5.5
590
2 - - 3.9
617
2 - - 41.4
651
2 - - 38.2
632
2 - - 6.3
610
2 - - 10.6
645
2 - - 0.0
589
2 - - 48.6
620
2 - - 0.0
611
2 - - 22.8
585
2 - - 9.7
622
2 - - 0.0
538
2 - - 24.6
601
2 - - 0.0
551
2 - - 6.7
531
2 - - 0.0
639
2 - - 7.4
577
2 - - 2.8
643
2 - - 0.0
618
2 - - 10.9
722
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
825
1 - - 0.0
834
1 - - 0.0
686
1 - - 0.0
690
1 - - 0.0
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