The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Bordetella uptake gene, domain 1

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Bordetella uptake gene, domain 1

Bug, for Boardetella Uptake Gene, proteins are a large family of periplasmic solute-binding proteins abundant in beta-proteobacteria. They adopt a characteristic Venus flytrap fold with two globular domains bisected by a ligand-binding cleft PMID:16403514. These proteins are specific for carboxylated solutes and show a characteristic mode of binding which involves two highly conserved beta strand-beta turn-alpha helix motifs originating from each domain. Structural domains comprising this superfamily share the structure of domain 1, involved in ligand recognition. However, stabilization of the closed conformation requires proper interactions to be established with domain 2, and thus domain 2 discriminates between productively and non-productively bound ligands PMID:17870093.

GO Diversity

Unique GO annotations
2 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
4575 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 8
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 2
Unique Species: 4575