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CATH Superfamily 3.40.140.80

LpxI C-terminal catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: LpxI C-terminal catalytic domain

Enzymes in lipid metabolism acquire and deliver hydrophobic substrates and products from within lipid bilayers. LpxI is an isozyme of a constitutive enzyme in lipid A biosynthesis. It is made up of 2 domains. This entry represents the C-terminal catalytic domain which comprises a five stranded beta-sheet bracketed by one alpha-helix on one side and three on the other. This domain has structural homology, though no sequence homology, to a superfamily that includes cytosine deaminase and various other proteins that do not share conservation of active sites or mechanisms PMID:23042606.

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
2121 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 3
Taxonomy
Unique Species: 2121