The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Cobalt-precorrin-4 Transmethylase; Domain 1

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tetrapyrrole methylase, N-terminal domain

This superfamily entry represents the N-terminal subdomain from several tetrapyrrole methylases. Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway PMID:11215515. Tetrapyrrole methylases catalyse the methylation of cyclic tetrapyrrole rings using methyl groups derived from S-adenosylmethionine (SAM) for the biosynthesis of modified tetrapyrroles such as cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin PMID:17227226. Enzymes in this superfamily include: S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase (SUMT) PMID:15522295, precorrin-2 C20-methyltransferase CobI/CbiL PMID:17229157, 17567575], precorrin-4 C11-methyltransferase CobM/CbiF PMID:16866557, sirohaem synthase CysG PMID:14595395 and diphthine synthase PMID:18391406.


GO Diversity

Unique GO annotations
29 Unique GO terms

EC Diversity

Unique EC annotations
18 Unique EC terms

Species Diversity

Unique species annotations
17808 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 229
Domain clusters (>95% seq id): 23
Domain clusters (>35% seq id): 12
Unique PDBs: 112
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 23
Unique EC: 18
Unique GO: 29
Unique Species: 17808