The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RRM (RNA recognition motif) domain

This superfamily consists of an RRM (RNA recognition motif) domain found in RNA binding proteins such as hnRNP proteins (heterogeneous nuclear ribonucleoproteins), in the ribosomal protein L23 in prokaryotes INTERPRO:IPR019985, proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu), and a few single stranded DNA binding proteins. The RRM domain consists of four anti-parallel beta-strands and two alpha-helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases. hnRNPs are involved in regulation of alternative splicing, and protein components of snRNPs.

Pfam [PfamClan:CL0221], PFAM:PF00076, INTERPRO:IPR000504, INTERPRO:IPR035979,PMID:8290338

GO Diversity

Unique GO annotations
1686 Unique GO terms

EC Diversity

Unique EC annotations
11 Unique EC terms

Species Diversity

Unique species annotations
25365 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1527
Domain clusters (>95% seq id): 351
Domain clusters (>35% seq id): 193
Unique PDBs: 1005
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3157
Function
Unique EC: 11
Unique GO: 1686
Taxonomy
Unique Species: 25365