The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Flavivirus RNA-directed RNA polymerase, thumb domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Flavivirus RNA-directed RNA polymerase, thumb domain

Alpha-beta plaits, associated literature shows this superfamily as the thumb domain of the finger/palm/thumb structure of a polymerase.

Thumb domain is required to increase processivity of the polymerase, so that the template doesn't have to bind the polymerase with each nucleic acid added to the growing strand

GO Diversity

Unique GO annotations
19 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
166 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 36
Domain clusters (>95% seq id): 8
Domain clusters (>35% seq id): 2
Unique PDBs: 24
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 5
Unique EC: 6
Unique GO: 19
Unique Species: 166