The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
MERS-CoV belongs to the beta-genus and uses human dipeptidyl peptidase 4 (DPP4) as its host receptor. Receptor recognition is a major determinant of coronavirus host range and tropism. An envelope-anchored trimeric spike protein is responsible for coronavirus entry into host cells via binding to the host receptor and subsequently fusing viral and host membranes. The spike protein consists of a receptor-binding S1 subunit and a membrane fusion S2 subunit. The S1 subunit consists of an N-terminal and a C-terminal domain, both of which can function as receptor-binding domains (RBD). However, it is the C-domain that interacts with DPP4.
This entry represents the core-subdomain of the RBD which is a five-stranded antiparallel beta-sheet with several short alpha-helices.
|Domain clusters (>95% seq id):||4|
|Domain clusters (>35% seq id):||2|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|