The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nucleotide cyclase
".
3.30.70.1230
superfamily
This superfamily comprises nucleotide cyclase structural domains, specifically a catalytic domain found in adenylate and guanylate cyclases. It has a ferredoxin-like fold with additional secondary structures, and is often known as the GGDEF domain, named after the conserved central sequence pattern GG[DE][DE]F. Though the fold of the GGDEF domain is similar to adenylate cyclase, the nucleotide-binding mode is substantially different PMID:15569936. It is typically present in multidomain proteins containing regulatory domains of signalling pathways or protein-protein or protein-ligand interaction modules, such as the response regulatory domain, the PAS/PAC domain, the HAMP domain, the GAF domain, the FHA domain or the TPR repeat. However a few single-domain proteins are also known. The GGDEF domain is involved in signal transduction and is likely to catalyse synthesis or hydrolysis of cyclic diguanylate (c-diGMP, bis(3',5')-cyclic diguanylic acid), an effector molecule that consists of two cGMP moieties bound head-to-tail.
PFAM:PF00211, INTERPRO:IPR029787, INTERPRO:IPR000160,PMID:11557134,PMID:11682196,PMID:11682196
Structures | |
---|---|
Domains: | 208 |
Domain clusters (>95% seq id): | 21 |
Domain clusters (>35% seq id): | 15 |
Unique PDBs: | 86 |
Alignments | |
Structural Clusters (5A): | 3 |
Structural Clusters (9A): | 2 |
FunFam Clusters: | 286 |
Function | |
Unique EC: | 4 |
Unique GO: | 406 |
Taxonomy | |
Unique Species: | 9489 |