The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Nonribosomal peptide synthetase, condensation domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nonribosomal peptide synthetase, condensation domain

This superfamily includes the condensation domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide (amide) bonds in non-ribosomal peptide biosynthesis PMID:26991102. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding, PFAM:PF00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site PMID:9712910.


GO Diversity

Unique GO annotations
81 Unique GO terms

EC Diversity

Unique EC annotations
11 Unique EC terms

Species Diversity

Unique species annotations
7130 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 24
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 9
Unique PDBs: 13
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 131
Unique EC: 11
Unique GO: 81
Unique Species: 7130