The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
983
3D
4k11A02 - 88.3
3
766
3D
4e68A04 - 96.0
2
762
3D
2l6kA01 - 78.8
4
759
3D
1opkA02 - 83.0
6
679
3D
5aulA00 - 88.0
5
676
3D
1tceA00 - 83.9
7
646
3D
3vrrA03 - 82.3
8
530
3D
2hdxF00 - 84.8
9
522
3D
4fbnA02 - 90.8
12
511
3D
6mddB02 - 86.3
10
506
3D
4tziB00 - 92.1
11
451
3D
4fbnA01 - 97.4
13
442 - - 95.3
14
425
3D
5gjiA00 - 75.4
18
422
3D
1aydA00 - 81.4
15
415
3D
3m7fA00 - 87.5
22
381
3D
5cdwd00 - 77.8
16
374
3D
2eo6A01 - 99.5
17
354 - - 74.7
19
342
3D
3cxlA01 - 95.6
20
337
3D
2kk6A00 - 82.9
21
327 - - 77.6
23
305
3D
3eazA00 - 89.7
24
296
3D
2rorA00 - 83.6
25
279 - - 74.4
26
265
3D
2eyzA01 - 75.0
27
260
3D
2ci9B00 - 69.5
28
237
3D
2izvA00 - 78.5
29
235 - - 83.6
31
228
3D
4fl3A01 - 88.6
30
218 - - 90.5
32
207 - - 60.0
33
192 - - 53.5
34
183 - - 79.4
35
180
3D
2mk2A00 - 74.4
36
179
3D
2vifA01 - 80.8
37
169 - - 78.5
38
157
3D
4fl3A03 - 69.8
39
145 - - 73.8
40
140
3D
2ge9A00 - 70.8
41
135 - - 70.0
42
134 - - 78.6
43
131
3D
2cr4A01 - 94.7
44
131
3D
2dlyA00 - 91.9
45
130
3D
2dm0A01 - 89.8
46
118 - - 44.6
49
114
3D
5bo4P01 - 73.0
47
114 - - 78.0
48
112 - - 81.2
50
105 - - 95.3
51
104 - - 98.1
52
102 - - 71.0
53
101 - - 72.7
54
96 - - 79.4
55
94 - - 70.7
56
94 - - 92.0
57
93 - - 89.3
61
93
3D
2k7aB00 - 73.5
58
92 - - 85.6
59
92
3D
2cs0A01 - 91.8
62
91
3D
1m27A00 - 28.9
60
91
3D
2ekxA01 - 73.9
65
85
3D
5vkoA02 - 92.5
63
82
3D
4xz1A03 - 54.9
66
77
3D
4gl9H00 - 79.3
64
75
3D
4m4zA02 - 71.4
67
63 - - 79.1
69
58
3D
1y1uC04 - 31.3
68
56 - - 52.0
70
55
3D
5gjhC00 - 29.1
77
52
3D
5mtnA00 - 57.2
71
50 - - 58.9
72
44 - - 46.1
73
40 - - 95.2
74
36
3D
1rjaA00 - 92.2
76
32
3D
2el8A01 - 38.6
75
32 - - 48.0
78
29 - - 76.1
79
28 - - 38.7
80
26 - - 94.8
84
24
3D
3mazA00 - 35.1
81
24 - - 94.2
82
24 - - 51.8
83
23 - - 17.9
85
23 - - 23.9
86
22 - - 67.3
87
21 - - 9.8
92
21
3D
1i3zA00 - 37.0
88
21 - - 50.4
90
19 - - 4.1
89
19 - - 90.7
91
19 - - 16.0
105
19
3D
5vkoA01 - 34.6
93
17 - - 20.3
94
15 - - 90.2
154
14
3D
5hl0A03 - 20.9
96
14 - - 71.0
95
14 - - 82.8
99
14
3D
1uusA04 - 78.0
97
13 - - 74.9
110
13
3D
3qwyB01 - 51.6
102
12 - - 56.5
101
12 - - 83.4
104
12 - - 96.1
98
12 - - 35.2
103
12 - - 75.9
100
12 - - 71.7
107
11 - - 1.2
106
11 - - 79.9
109
10 - - 43.0
112
10 - - 49.7
108
10 - - 79.8
111
10 - - 18.4
114
8 - - 19.5
115
8 - - 70.9
113
8 - - 41.0
116
8 - - 74.1
120
8
3D
1aouF00 - 37.3
118
7 - - 29.1
119
7 - - 72.9
117
7 - - 79.6
124
6 - - 9.8
122
6 - - 61.5
125
6 - - 13.6
121
6 - - 14.1
126
6 - - 50.2
123
6 - - 9.0
127
5 - - 36.1
129
5 - - 86.2
135
5 - - 70.9
131
5 - - 9.4
136
5 - - 92.2
132
5 - - 16.7
133
5 - - 7.2
128
5 - - 63.1
134
5 - - 9.4
130
5 - - 19.0
139
4 - - 65.8
145
4 - - 6.0
140
4 - - 78.7
144
4 - - 18.3
143
4 - - 8.0
138
4 - - 69.7
137
4 - - 48.5
142
4 - - 8.8
141
Ras/Rab INteractor
4 - - 9.1
146
4 - - 88.2
153
3 - - 11.5
159
3 - - 6.6
160
3 - - 73.5
162
3 - - 9.7
152
3 - - 3.1
158
3 - - 1.8
161
3 - - 11.9
151
3 - - 0.0
148
3 - - 73.9
157
3 - - 1.2
147
3 - - 30.6
149
3 - - 48.7
156
3 - - 3.1
150
3 - - 43.8
155
3 - - 0.0
194
2 - - 1.2
163
2 - - 12.5
175
2 - - 2.0
199
2 - - 33.8
198
2 - - 0.0
202
2 - - 0.0
168
2 - - 42.8
184
2 - - 1.5
178
2 - - 3.3
181
2 - - 3.9
195
2 - - 8.0
193
2 - - 0.0
180
2 - - 0.0
201
2 - - 0.0
189
2 - - 35.1
174
2 - - 4.7
188
2 - - 0.0
177
2 - - 0.0
183
2 - - 0.0
169
2 - - 43.2
171
2 - - 44.6
200
2 - - 44.9
190
2 - - 43.8
197
2 - - 0.0
203
2 - - 1.3
204
2 - - 7.6
165
2 - - 17.6
186
2 - - 9.2
191
2 - - 51.5
172
2 - - 44.9
187
2 - - 4.9
176
2 - - 0.0
170
2 - - 47.9
179
2 - - 0.0
182
2 - - 0.0
167
2 - - 29.2
173
2 - - 46.0
166
2 - - 22.6
192
2 - - 41.8
185
2 - - 1.6
164
2 - - 16.5
196
2 - - 3.3
206
1 - - 0.0
233
1 - - 0.0
259
1 - - 0.0
220
1 - - 0.0
208
1 - - 0.0
226
1 - - 0.0
211
1 - - 0.0
241
1 - - 0.0
236
1 - - 0.0
249
1 - - 0.0
218
1 - - 0.0
234
1 - - 0.0
270
1 - - 0.0
244
1 - - 0.0
246
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
266
1 - - 0.0
214
1 - - 0.0
221
1 - - 0.0
229
1 - - 0.0
260
1 - - 0.0
237
1 - - 0.0
222
1 - - 0.0
254
1 - - 0.0
217
1 - - 0.0
239
1 - - 0.0
205
1 - - 0.0
269
1 - - 0.0
235
1 - - 0.0
213
1 - - 0.0
265
1 - - 0.0
272
1 - - 0.0
243
1 - - 0.0
231
1 - - 0.0
261
1 - - 0.0
247
1 - - 0.0
228
1 - - 0.0
268
1 - - 0.0
224
1 - - 0.0
223
1 - - 0.0
262
1 - - 0.0
212
1 - - 0.0
238
1 - - 0.0
251
1 - - 0.0
253
1 - - 0.0
209
1 - - 0.0
256
1 - - 0.0
216
1 - - 0.0
227
1 - - 0.0
264
1 - - 0.0
255
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
263
1 - - 0.0
210
1 - - 0.0
258
1 - - 0.0
252
1 - - 0.0
250
1 - - 0.0
215
1 - - 0.0
271
1 - - 0.0
245
1 - - 0.0
267
1 - - 0.0
219
1 - - 0.0
257
1 - - 0.0
248
1 - - 0.0
242
1 - - 0.0