The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

6-pyruvoyl tetrahydropterin synthase/QueD

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: 6-pyruvoyl tetrahydropterin synthase/QueD

According to available literature members of this superfamily share structure of the enzyme 6-Pyruvoyl tetrahydrobiopterin synthase (PTPS), involved in the second of three steps in tetrahydrobiopterin synthesis. This domain is annotated in InterPro as a catalytic domain (INTERPRO:IPR007115).

It is important to note that the function of this domain was thought to be the same in the bacterial branch of the superfamily but, many are now taken to be QueD, and enzyme of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of some tRNAs in most species (INTERPRO:IPR007115).

GO Diversity

Unique GO annotations
17 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
9824 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 86
Domain clusters (>95% seq id): 10
Domain clusters (>35% seq id): 6
Unique PDBs: 21
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 18
Unique EC: 3
Unique GO: 17
Unique Species: 9824