The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Branched-chain aminotransferase (BCAT) catalyses the transamination of the branched-chain amino acids leucine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two forms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme PMID:12686109. BCATs belong to the class 4 type aminotransferases and are widely distributed in many species PMID:22984263. This entry represents the N--terminal domain of BCATs. PMID:12686109 PMID:22984263

GO Diversity

Unique GO annotations
53 Unique GO terms

EC Diversity

Unique EC annotations
26 Unique EC terms

Species Diversity

Unique species annotations
13082 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 247
Domain clusters (>95% seq id): 31
Domain clusters (>35% seq id): 18
Unique PDBs: 93
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 16
Unique EC: 26
Unique GO: 53
Unique Species: 13082