The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: NADH:ubiquinone oxidoreductase, 30kDa subunit

NADH:ubiquinone oxidoreductase, also know as complex I, is one of the respiratory chain components (complexes I-IV and ATP synthase) in the mitochondrial inner membrane of eukaryotes or the plasma membrane of prokaryotes which carries out an electron transfer reaction from NADH to ubiquinone, process linked to the pumping of protons across the inner mitochondrial membrane and this generates a proton concentration gradient.

Structural domains comprising this superfamily share the structure of the 30kDa subunit of this complex, of which the bacterial homologue is denoted Nqo5. The subunit composes the hydrogenase-like module together with the Nqo4, Nqo6, and Nqo9 subunits. Homologous proteins of the Nqo5 subunit are also contained in membrane-bound multisubunit hydrogenases, while soluble-type hydrogenases are not. This subunit is essential in complex I assembly PMID:27398308.

GO Diversity

Unique GO annotations
31 Unique GO terms

EC Diversity

Unique EC annotations
8 Unique EC terms

Species Diversity

Unique species annotations
12537 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 8
Unique GO: 31
Unique Species: 12537