The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Longin domain

SNARE-mediated fusion typically results in the formation a complex consisting of three Q-SNAREs and one R-SNARE. Concerning R-SNAREs, we can distinguish between two subfamilies of short VAMPs or brevins, and of long VAMPs or longins because only the latter share a N-terminus extension, the so-called Longin domain, LD. VAMPS are characterised by the presence of a C-terminal coiled-coil/SNARE domain, together with variable N-terminal domains that are used for their classification, as described PMID:15145528.

Longins are the only type of VAMP protein found in all eukaryotes, suggesting that their longin domain (LD) is essential. Structural domains comprising this superfamily share the structure of this domain, which has profilin-like structural fold and is thought to exert a regulatory function. The best characterised longins are those encoded by the yeast Saccharomyces cerevisiae: Sec22p, Ytk6p, and Nyv1p PMID:16855025.

GO Diversity

Unique GO annotations
138 Unique GO terms

EC Diversity

Unique EC annotations
8 Unique EC terms

Species Diversity

Unique species annotations
1660 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 18
Domain clusters (>95% seq id): 8
Domain clusters (>35% seq id): 6
Unique PDBs: 13
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 9
Unique EC: 8
Unique GO: 138
Unique Species: 1660