View in Gene3D

CATH Superfamily 3.30.450.280

GAF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
GAF domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GAF domain

Structural domains comprising this superfamily share the structure of the GAF domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains (Superfamily 3.30.450.20), both are ubiquitous and form dimeric interfaces.

GAF domains are known to bind heme (as can PAS domains), to be involved in redox responses and even to function as catalytic domains PMID:22115998.

GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1863 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 5
Taxonomy
Unique Species: 1863