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CATH Superfamily 3.30.450.200

Longin module

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Longin module

Rab GTPases are key regulators of membrane traffic pathways within eukaryotic cells. They are specifically activated by guanine nucleotide exchange factors (GEFs), which convert them from their inactive GDP-bound form to the active GTP-bound form. In higher eukaryotes, proteins containing DENN-domains comprise a major GEF family. The N-terminal half of the DENN domain folds into a longin module, consisting of a central antiparallel beta-sheet layered between three alpha-helices. This entry represents the longin module PMID:22065758.

GO Diversity

Unique GO annotations
105 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
786 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 26
Function
Unique EC:
Unique GO: 105
Taxonomy
Unique Species: 786