The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ribosomal protein S11

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein S11/S14

This superfamily entry represents the ribosomal protein S11, located on the large lobe of the small ribosomal subunit. This entry includes bacterial S11 and its homologues in bacterial, archaeal and eukaryotic ribosomes (it is known as S14 in eukaryotes).

S11 has a distinctive protein architecture comprised of five beta sheets packed against two alpha helices, resembling the RRM RNA binding motif. Interestingly, S11 does not use the side of the beta sheet to contact RNA, as most RRM-containing proteins do, but uses the flat side of the antiparallel part of the beta sheet for its RNA interactions. Further contacts between S11 and rRNA are established via the 17 amino acid residue C-terminal tail of S11.

S11 plays an essential role in selecting the correct tRNA in protein biosynthesis. In Saccharomyces cerevisiae, rpS14 is an essential protein necessary for the assembly of 40 S ribosomal subunits.

PFAM:PF00411, INTERPRO:IPR036967,PMID:14568531,PMID:3191988,PMID:24823650

GO Diversity

Unique GO annotations
63 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
22646 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 432
Domain clusters (>95% seq id): 16
Domain clusters (>35% seq id): 3
Unique PDBs: 426
Structural Clusters (5A): 3
Structural Clusters (9A): 2
FunFam Clusters: 39
Unique EC:
Unique GO: 63
Unique Species: 22646