The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

eRF1 domain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: eRF1 domain 2

Structural domains which comprise this superfamily share the structure of a conserved region in the release factor eRF1, designated domain 1. eRF1 is involved in termination of protein biosynthesis through stop codon recognition at the A site of the ribosome and stimulation of peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre PMID:10676813. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The presence of the essential GGQ motif at an exposed tip of domain 2 suggests that this motif plays a direct role at the catalytic site of the peptidyl transferase center PMID:10676813.

GO Diversity

Unique GO annotations
51 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
3481 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 25
Domain clusters (>95% seq id): 10
Domain clusters (>35% seq id): 8
Unique PDBs: 14
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 22
Unique EC:
Unique GO: 51
Unique Species: 3481