The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: FAD/NAD-linked reductase, C-terminal dimerisation domain

This superfamily represents the C-terminal domain in FAD- and NAD-linked reductases, which participates to dimerisation. This structural domain has a core alpha+beta sandwich structure consisting of beta(3,4)-alpha(3). The first two domains are of the same beta/beta/alpha fold. This domain can be found in several reductases such as: glutathione, trypanothione, thioredoxin, putidaredoxin reductases PMID:3656429,PMID:2355009,PMID:18300227,PMID:15299452,PMID:8771196,PMID:11481439,PMID:15095867, apoptosis-inducing factor (AIF), which contains a beta-hairpin loop insertion involved in its apoptogenic functions PMID:11967568,PMID:12198487, dihydrolipoyl dehydrogenase (also known as dihydrolipoamide dehydrogenase) PMID:8805537, NADH peroxidases PMID:7766608,PMID:1942054, biphenyl 2,3-dioxygenase, ferredoxin reductase (also known as NADH-dependent ferredoxin reductase, BphA4) PMID:11090282, 2-oxopropyl-CoM reductase (also known as NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase) PMID:12390015, flavocytochrome c sulphide dehydrogenase (FCSD), the flavin-binding subunit INTERPRO:IPR015323, INTERPRO:IPR037092,PMID:7939681.

Pfam clan [PfamClan:CL0608], INTERPRO:IPR016156

GO Diversity

Unique GO annotations
244 Unique GO terms

EC Diversity

Unique EC annotations
21 Unique EC terms

Species Diversity

Unique species annotations
16775 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 533
Domain clusters (>95% seq id): 71
Domain clusters (>35% seq id): 27
Unique PDBs: 240
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 52
Function
Unique EC: 21
Unique GO: 244
Taxonomy
Unique Species: 16775