The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Polymerase Basic Protein 2, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Polymerase Basic Protein 2, C-terminal domain

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the C-terminal domain in the PB2 subunit of the trimeric influenza virus polymerase. This is an RNA polymerase involved in the transcription and replication of its segmented RNA genome. The C-terminal domain of PB2 forms a stable complex with human importin alpha5 in vitro which, suggests that this domain directs nuclear import. This is further backed by the presence of a previously missed bipartite nuclear localization sequence (NLS) within this domain PMID:17310249

GO Diversity

Unique GO annotations
16 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
4020 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 14
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 11
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 16
Unique Species: 4020