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CATH Superfamily 3.30.2410.10

Hect, E3 ligase catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
E3 ubiquitin-protein ligase NEDD4-like
1704
3D
 4be8A03 - 87.4
2
E3 ubiquitin-protein ligase HECW2
1359
3D
 1nd7A03 - 92.6
3
probable E3 ubiquitin-protein ligase HERC4 isoform X1
760 - - 97.6
4
E3 ubiquitin-protein ligase HUWE1, variant
634
3D
 3h1dA03 - 83.2
5
E3 ubiquitin-protein ligase TRIP12 isoform X1
505 - - 76.6
6
probable E3 ubiquitin-protein ligase HERC1 isoform X2
445 - - 91.2
7
Putative E3 ubiquitin-protein ligase HECTD1
376 - - 90.3
8
Putative E3 ubiquitin-protein ligase UBR5
366
3D
 3pt3B00 - 81.4
9
Probable E3 ubiquitin-protein ligase HECTD2
340 - - 95.5
10
E3 ubiquitin-protein ligase UPL1
294 - - 77.0
11
Putative Ubiquitin-protein ligase E3C
293 - - 73.7
12
Ubiquitin-protein ligase E3B
283 - - 74.6
13
Apoptosis-resistant E3 ubiquitin protein ligase 1
278 - - 78.5
14
E3 ubiquitin-protein ligase SMURF1
261
3D
 1zvdA03 - 76.5
15
probable E3 ubiquitin-protein ligase HECTD4 isoform X1
254 - - 40.5
16
E3 ubiquitin-protein ligase HACE1 isoform X1
218 - - 61.0
17
E3 ubiquitin-protein ligase UPL7
148 - - 90.1
18
Putative E3 ubiquitin-protein ligase HECTD3
110 - - 32.1
19
G2/M-phase specific E3 ubiquitin protein ligase
49 - - 17.6
20
E3 ubiquitin-protein ligase UPL5
29 - - 81.4
21
Putative ubiquitin-protein ligase
18 - - 58.6
22
Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence
15 - - 45.0
23
E3 ubiquitin-protein ligase
12 - - 33.5
24
E3 ubiquitin-protein ligase hecw-1
12 - - 80.5
25
Ubiquitin ligase
E3
10 - - 12.7
26
Zn-finger in Ran binding protein and others/SPRY domain/HECT-domain
Ubiquitin-transferase
9 - - 42.2
27
E3 ubiquitin-protein ligase HUWE1
9 - - 8.3
29
Ubiquitin protein ligase E3A
7 - - 9.0
28
Ubiquitin protein ligase, putative
7 - - 2.1
33
Predicted protein
6 - - 93.3
30
Predicted protein
6 - - 88.9
32
E3 ubiquitin-protein ligase HACE1
6 - - 25.0
31
Hectd1 protein
6 - - 3.6
34
WWP1 isoform 12
5 - - 21.8
37
E3 ubiquitin-protein ligase pub2
4 - - 69.2
36
Ubiquitin-protein ligase, putative
4 - - 59.2
35
E3 ubiquitin-protein ligase
4 - - 30.7
39
E3 ubiquitin-protein ligase HACE1
3 - - 3.1
41
Uncharacterized protein
3 - - 52.8
43
Uncharacterized protein
3 - - 71.7
40
Ubiquitin protein ligase E3 component n-recognin 5
3 - - 31.2
38
HECT-domain ubiquitin--protein ligase E3
3 - - 8.4
42
MKIAA1625 protein
3 - - 47.1
48
E3 ubiquitin-protein ligase
2 - - 7.7
46
Ubiquitin-protein ligase E3B
2 - - 0.0
44
Uncharacterized protein
2 - - 47.0
49
Thyroid hormone receptor interactor 12
2 - - 7.7
45
Predicted protein
2 - - 0.0
47
E3 ubiquitin-protein ligase
2 - - 0.0
60
Uncharacterized protein
1 - - 0.0
62
Uncharacterized protein
1 - - 0.0
56
Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
1 - - 0.0
58
Uncharacterized protein
1 - - 0.0
51
Probable E3 ubiquitin protein ligase C167.07c
1 - - 0.0
65
Uncharacterized protein
1 - - 0.0
53
Uncharacterized protein
1 - - 0.0
67
Uncharacterized protein
1 - - 0.0
61
Uncharacterized protein
1 - - 0.0
55
Uncharacterized protein
1 - - 0.0
63
Uncharacterized protein
1 - - 0.0
50
E3 ubiquitin-protein ligase etc-1
1 - - 0.0
57
Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
1 - - 0.0
64
Uncharacterized protein
1 - - 0.0
52
Probable E3 ubiquitin-protein ligase mug30
1 - - 0.0
66
Predicted protein
1 - - 0.0
59
Uncharacterized protein
1 - - 0.0
54
Protein CBG00511
1 - - 0.0