View in Gene3D

CATH Superfamily 3.30.1600.10

SIR2/SIRT2 'Small Domain'

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SIR2/SIRT2 'Small Domain'
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
NAD-dependent deacetylase sirtuin-3, mitochondrial
499
3D
 5fyqB02 - 88.7
2
NAD-dependent protein deacylase
258
3D
 1s5pA02 - 74.2
3
NAD-dependent histone deacetylase sirtuin-1
243 - - 86.6
5
NAD-dependent protein deacylase sirtuin-5, mitochondrial
170
3D
 6eqsD02 - 88.0
4
NAD-dependent deacetylase sir2A
125
3D
 4iaoB03 - 83.9
6
SIR2 family histone deacetylase
90 - - 93.8
7
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
61 - - 76.0
8
NAD-dependent protein deacetylase sirtuin-1
50
3D
 4zzjA03 - 41.7
9
Nad-dependent deacetylase 1 putative
43
3D
 4bv2B02 - 93.2
11
NAD-dependent protein deacylase
21
3D
 3u3dA02 - 5.8
10
NAD-dependent protein deacetylase
20 - - 15.4
12
NAD-dependent protein deacetylase
18 - - 49.0
13
NAD-dependent protein deacetylase sirtuin-1
16
3D
 4zziA03 - 51.5
14
NAD-dependent histone deacetylase SIR2
10 - - 85.5
15
NAD-dependent protein deacylase
7 - - 10.2
16
Sirtuin 5 and related class III sirtuins
7 - - 5.7
18
NAD-dependent deacetylase, Sir2 family protein
6 - - 7.0
17
SIR2 family protein
6 - - 6.0
20
Related to NAD-dependent histone deacetylase
5 - - 53.2
19
NAD-dependent protein deacetylase
5 - - 0.0
21
NAD-dependent histone deacetylase Sir2
5 - - 7.7
22
Uncharacterized protein
4 - - 5.2
23
Transcriptional regulator, Sir2 family protein
3 - - 78.6
29
NAD-dependent protein deacetylase
2 - - 0.0
26
NAD-dependent protein deacetylase 2
2 - - 0.0
25
Sirtuin type 2
2 - - 0.0
27
NAD-dependent protein deacylase SIR2rp2
2 - - 0.0
28
NAD-dependent protein deacetylase
2 - - 8.1
24
DHS-like NAD/FAD-binding domain-containing protein
2 - - 0.0
30
Uncharacterized protein
2 - - 30.5
39
Uncharacterized protein
1 - - 0.0
35
NAD-dependent deacetylase sir2C
1 - - 0.0
36
NAD-dependent deacetylase sir2E
1 - - 0.0
32
Uncharacterized protein
1 - - 0.0
31
Predicted protein
1 - - 0.0
40
Uncharacterized protein
1 - - 0.0
37
Sirtuin type, putative
1 - - 0.0
41
Sirtuin 7
1 - - 0.0
33
Uncharacterized protein
1 - - 0.0
38
Uncharacterized protein
1 - - 0.0
42
Class IV sirtuin
1 - - 0.0
34
Histone deacetylase HDAC silent information regulator protein 2 Sir2 sirtuin
1 - - 0.0