The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Sufu, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sufu, C-terminal domain

Sufu (suppressor of Fused Gli/Ci) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding to these proteins and preventing their translocation to the nucleus. Sufu possesses an extended dumb-bell-like shape, with a short linker functioning as a hinge connecting the two globular NTD and CTD domains. The Sufu C-terminal domain binds to the N-terminal of Gli/Ci, while the N-terminal of Sufu binds to the C-terminal of Gli/Ci. This dual binding mechanism is likely to be an evolutionary advancement in this signalling cascade, which is not present in bacterial homologues.

This superfamily represents the C-terminal domain of suppressor of fused. It folds into a domain that comprises a four-stranded and a six-stranded beta-sheet, both with mixed topologies, which are connected by two antiparallel alpha-helices.


GO Diversity

Unique GO annotations
43 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
295 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 24
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 10
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 5
Unique EC:
Unique GO: 43
Unique Species: 295