The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nucleosome assembly protein

Structural domains comprising this superfamily share the structure of the nucleosome assembly proteins (NAPs), histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. NAPs participate in the assembly and disassembly of nucleosomes and therefore contribute to chromatin structure organization. Chromatin assembly and remodeling are vital cellular processes that are pivotal during replication, transcription, recombination, and repair in eukaryotic cells PMID:17360516.

Understanding NAPs mechanism of action is also key in the context of malaria as it is one of the most common infectious diseases and represents an enormous public health problem. Malaria is caused by protozoan parasites of the genus Plasmodium, and the most severe for of the disease is caused by Plasmodium falciparum. The plasmodium parasite genome encodes for two nucleosome assembly proteins, designated PfNapL and PfNapS, which are orthologs of eukaryotic NAPs and are present in all erythrocytic stages of the parasite. PfNapL forms complexes with both histone tetramer and octamer and is predominantly localized in the cytoplasm in the asexual and sexual stages of the parasite and, even though its itself is unable to deposit the histones onto DNA, it can interact with both core and linker histones and is involved in histone binding, shuttling, and transfer/release. PfNapL transfers cytoplasmic histones on to PfNapS. The key finding is that parasite NAPs are sufficiently different from their counterparts in other species and thus they constitute a unique opportunity for the exploration as anti-malarial targets PMID:19176479,PMID:20377878.

GO Diversity

Unique GO annotations
100 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
1415 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 16
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 6
Unique GO: 100
Unique Species: 1415