The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
16199
14269
EC
3D
3q3fA02 - 87.2
16135
5069
3D
4co7A00 - 79.6
16490
4252
EC
3D
3pgeA01 - 89.7
16531
3526
EC
3D
1m94A00 - 76.4
16333
2509
EC
3D
1nddA00 - 75.6
16211
2093
3D
1gg3A02 - 88.8
3699
1882
3D
1wghA01 - 80.2
16502
1735
EC
3D
1vd2A00 - 90.4
16491
1570
3D
1i42A00 - 90.2
16446
1466
EC
3D
2kx3A00 - 97.4
16440
1394
3D
1oqyA01 - 86.0
16558
1343
3D
1wgrA01 - 74.6
16295
1335
EC
3D
1ni2A01 - 90.0
16362
1295
EC
- - 90.2
16431
1268
3D
3w1sC00 - 90.3
16105
1203
3D
5dprA00 - 90.7
16438
1000
EC
- - 93.1
16015
952
3D
1wxsA00 - 91.3
16452
859
3D
1raxA00 - 88.3
16323
830
3D
1wmhB00 - 89.8
16627
789
EC
3D
1zkhA00 - 84.6
16481
712
EC
3D
2kc2A00 - 84.6
16451
688
EC
3D
3pvlA02 - 97.3
16437
630
EC
3D
1wggA01 - 96.4
16568
623 - - 96.1
15968
621
3D
3ig3A02 - 72.1
16521
621
EC
3D
1c1yB00 - 82.9
16271
600 - - 94.6
16143
554
3D
4x57B00 - 96.7
16261
530
EC
- - 80.2
16309
513
3D
2klcA00 - 99.8
16455
462 - - 81.3
16710
458
EC
3D
3ppaA02 - 91.6
16640
441
3D
3goeA00 - 88.8
16409
434
3D
1wx9A00 - 98.6
16573
398
EC
3D
2fazA00 - 97.0
16130
366 - - 90.0
16442
359 - - 93.8
16183
340
3D
2cs4A00 - 73.0
16106
339 - - 82.7
16287
336
3D
2kc1A00 - 87.0
16354
332 - - 81.7
16297
331
EC
3D
2lgyA00 - 91.6
16401
328
EC
- - 87.9
16632
316
EC
3D
1e8yA01 - 95.8
16270
296
EC
3D
2v3sA00 - 84.5
1161
278
3D
1lm8B00 - 84.9
16033
247
EC
3D
2rd0A01 - 60.6
1977
229 - - 58.9
15929
223
EC
3D
2byfA01 - 76.8
16041
221 - - 48.1
16516
219
EC
3D
1mg8A00 - 97.1
7242
200 - - 84.6
16192
194 - - 38.6
16274
191
3D
2dziA00 - 92.8
16559
188
EC
3D
1k8rB00 - 94.4
15946
188
EC
3D
4ny0A01 - 67.5
16668
185 - - 90.0
16539
181 - - 92.7
10384
179 - - 75.0
3096
177 - - 69.1
16292
176 - - 88.5
16463
176
EC
3D
1wh3A01 - 95.3
16537
173
EC
3D
2lwpA00 - 95.5
15989
171
EC
- - 55.3
15902
169 - - 73.0
10380
167 - - 52.8
16624
165 - - 93.7
7637
163
EC
3D
2cu1A01 - 59.1
3088
162 - - 42.7
16236
156 - - 74.1
7934
151
EC
3D
2c60A01 - 64.4
5805
151 - - 31.9
1921
147
3D
1wxaA00 - 44.2
15065
144 - - 62.2
16218
144
3D
5khoA00 - 72.5
16159
143
EC
- - 55.3
14602
139
3D
2al3A00 - 90.5
16168
137
EC
3D
1h8cA00 - 58.9
15995
136 - - 69.3
15924
134
EC
- - 44.0
13597
131 - - 24.6
5804
129
EC
3D
2nptA01 - 54.4
2199
129
3D
3kuzA00 - 70.0
5506
125
EC
- - 42.9
9313
123 - - 0.0
16124
122
EC
- - 74.3
7591
120 - - 28.8
13807
120 - - 65.2
16707
118
EC
3D
4ekuA01 - 88.6
16152
117 - - 81.8
10971
116 - - 54.6
15935
115
3D
1ttnA01 - 30.8
8401
114
EC
3D
2dzjA00 - 50.2
15952
113 - - 77.1
1584
111 - - 29.7
16223
110
3D
1wiaA01 - 75.2
11537
109
EC
- - 32.0
15896
108 - - 58.0
16123
107
EC
3D
4e3cA02 - 77.7
7537
105
3D
1wj6A01 - 50.1
5002
103 - - 53.7
4555
103
3D
3au4A02 - 29.1
16620
102
3D
1pqsA00 - 93.9
300
101
3D
2kxjA00 - 41.8
16254
99
3D
2bweS00 - 52.0
16288
94
3D
1wgdA00 - 80.3
16492
93
EC
- - 98.4
8917
93
EC
- - 27.9
16056
92 - - 65.5
16706
92
EC
- - 92.9
16032
92
3D
4gxbA01 - 42.1
9738
92 - - 44.6
16012
92
EC
- - 39.2
2572
91
3D
2nbuA00 - 10.4
533
90 - - 72.8
15897
89 - - 41.6
2828
87
EC
3D
4mjsB00 - 76.2
16006
87
EC
- - 53.8
3075
85 - - 0.0
16239
81
EC
- - 55.9
3765
U11/U12
81 - - 25.8
14029
81 - - 0.0
6582
80 - - 34.0
2847
80 - - 29.8
15969
79 - - 77.7
834
79 - - 19.9
15984
79 - - 59.9
16651
77
EC
- - 86.8
15906
77 - - 74.6
8558
73 - - 76.3
15932
73
EC
- - 45.8
4997
72 - - 74.8
15892
72 - - 39.8
13116
70 - - 43.3
16150
69
3D
1wjnA00 - 56.3
15920
68
EC
3D
2byeA01 - 44.2
15936
67
EC
- - 28.5
16265
66
3D
1z2mA02 - 71.9
8043
64
3D
2uwqA00 - 27.8
13622
63
3D
2dhzA01 - 23.3
6162
61 - - 73.7
15945
60
3D
1v6eA01 - 41.2
9871
55 - - 49.6
10977
54 - - 59.1
15959
53 - - 38.6
16212
53 - - 54.3
16097
51
3D
1oeyA00 - 55.9
16023
51
EC
3D
4bfrA01 - 44.4
5426
51 - - 65.3
6138
51 - - 21.6
15966
51 - - 52.2
5495
50
EC
- - 29.6
4155
50 - - 0.0
16424
50
3D
2mbeA00 - 74.8
15998
49 - - 48.2
501
49 - - 2.9
15904
48 - - 14.1
16139
48 - - 74.0
1922
47 - - 20.3
16091
45
EC
3D
1iyfA00 - 30.2
9996
45
EC
- - 16.1
13389
44 - - 26.3
16178
38
EC
- - 60.6
16013
38
EC
- - 33.8
14820
37 - - 85.2
2523
36
EC
- - 17.5
16688
36 - - 79.0
2958
36
EC
- - 0.0
15893
36
3D
2dybA03 - 45.7
16203
35
3D
1wfyA01 - 47.5
2093
35 - - 4.4
16296
35
3D
1z2mA01 - 66.4
16626
34 - - 63.7
15909
34 - - 45.5
7539
34 - - 32.7
10426
31 - - 3.1
16367
31 - - 69.4
15454
30
3D
1v2yA00 - 79.9
16468
29
EC
- - 38.0
13809
26 - - 19.1
4269
25
EC
- - 29.1
13825
25 - - 5.9
16415
23 - - 13.0
6485
21 - - 15.8
10973
20 - - 14.8
15962
20
3D
2jphA00 - 33.3
13822
19
EC
- - 10.8
6910
18
EC
- - 21.5
15882
18
3D
4ajwA01 - 52.7
5795
18 - - 22.4
9314
17 - - 34.1
13808
16
EC
- - 11.0
7258
16
EC
- - 30.4
1516
16 - - 5.8
7195
15 - - 20.6
307
15 - - 14.6
2710
15 - - 30.8
10980
15
3D
4hwiB01 - 20.2
6197
13
EC
- - 19.4
15871
13 - - 41.4
8588
12 - - 4.2
7042
12 - - 29.9
15922
12 - - 0.0
4444
12 - - 12.4
10477
12
EC
- - 11.4
11765
12 - - 4.0
10098
12 - - 4.4
3786
11 - - 7.0
12685
11
EC
- - 7.9
16063
11
EC
- - 23.0
16601
11 - - 45.0
7645
11 - - 16.5
8997
10 - - 20.2
939
10 - - 0.0
8399
9 - - 17.5
12245
9 - - 0.0
9312
9 - - 11.8
2727
9
EC
- - 15.6
16008
9 - - 30.3
4939
9 - - 35.6
1718
8 - - 8.3
6144
8
EC
- - 5.7
12554
8 - - 0.0
15457
8 - - 26.2
15211
8 - - 26.7
6467
7 - - 12.0
15853
7
3D
2rd0A02 - 17.9
7587
6 - - 15.3
4836
6
EC
- - 9.3
10901
6 - - 18.1
6226
6
EC
- - 14.8
9990
6 - - 4.1
10271
6 - - 12.7
15982
6 - - 34.3
6140
5 - - 0.0
8179
5
EC
- - 12.1
158
5 - - 14.1
10555
5 - - 9.0
5126
5 - - 9.6
6465
5 - - 6.1
2608
5 - - 12.0
8413
5
EC
- - 7.8
5811
5 - - 0.0
16423
4 - - 67.6
7579
4 - - 6.0
12561
4 - - 0.0
16548
4
EC
- - 59.3
8861
4 - - 7.3
11619
3
EC
- - 9.6
10550
3
EC
- - 11.3
4000
3 - - 4.6
16654
3
EC
- - 55.5
7207
3 - - 2.9
12250
3
EC
- - 3.7
16019
3 - - 18.5
16403
3 - - 45.2
14049
3
EC
- - 4.5
7531
2 - - 5.2
14849
2 - - 0.0
16414
AFU_orthologue; AFUA_4G04120
2 - - 46.1
9045
2 - - 6.8
10285
2
EC
- - 7.7
4220
2 - - 3.5
9623
2
EC
- - 7.1
14782
2 - - 0.0
5814
2
EC
- - 12.4
8410
2 - - 8.9
13629
2
EC
- - 0.0
10984
2
EC
- - 4.6
15993
2 - - 9.4
6506
2 - - 1.4
5807
2 - - 0.0
6078
2 - - 6.8
4558
2 - - 0.0
7975
2 - - 5.2
7530
2
EC
- - 7.0
7117
2 - - 9.7
7936
2 - - 9.2
15040
1
EC
- - 0.0
16182
1 - - 0.0
6471
1 - - 0.0
5566
1
EC
- - 0.0
2209
1 - - 0.0
8403
1 - - 0.0
6145
1 - - 0.0
14562
1 - - 0.0
13162
1 - - 0.0
14180
1 - - 0.0
5812
1 - - 0.0
4158
1 - - 0.0
3933
1 - - 0.0
14456
1
EC
- - 0.0
8591
1 - - 0.0