The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

ASAP complex, SAP18 subunit

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ASAP complex, SAP18 subunit

This superfamily includes of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides PMID:9150135. SAP18 [UBL domain] is one of the three three ASAP subunits (along with Acinus [beta-hairpin motif] and RNPS1 [RRM domain]) that play a role in programmed cell death, transcriptional regulation, pre-mRNA splicing and mRNA quality control PMID:12665594,PMID:22388736. The ASAP complex interacts with the exon-junction complex (EJC), a messenger ribonucleoprotein complex involved in post-transcriptional regulation.

According to literature, the high degree of evolutionary conservation and the fortuitous crystal contacts at the alpha-beta groove suggest that this surface of SAP18 is a hot spot for interactions. Possible binding partners targeting this surface of SAP18 are transcription factors (such as Bicoid and Kruppel) and/or Sin3a-HDAC subunits.

DOI:10.1038/nsmb.2242, PFAM:PF06487, INTERPRO:IPR010516

GO Diversity

Unique GO annotations
30 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1206 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC:
Unique GO: 30
Unique Species: 1206