The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:


Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Spindlin/Ssty

Structural domains comprising this superfamily share the structure of the Spindlin(Spin)/Ssty family of proteins, first identified for their involvement in gametogenesis. Spindlin is a maternal transcript present in the unfertilised egg and early embryo, and it interacts with the spindle apparatus during oogenesis, suggesting it might also be important for mitosis PMID:9053325. Spindlin also appears to be a target for cell cycle-dependent phosphorylation, so it may play a role in cell cycle regulation during the transition from gamete to embryo PMID:11806826. Ssty is a multi-copy, Y-linked spermatogenesis-specific transcript required for normal spermatogenesis PMID:15020475. It is also thought that Ssty plays an analogous role to spindlin in sperm cells, specifically during the transition from sperm cells to early embryo, and in mitosis.

GO Diversity

Unique GO annotations
12 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
200 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 17
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 9
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Unique EC:
Unique GO: 12
Unique Species: 200