The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

GTP1/OBG domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GTP1/OBG domain

Obg is a unique family of high-molecular mass GTPases conserved from bacteria to eukaryotes. In bacteria, Obg is essential for cellular growth, sporulation, and differentiation. These proteins comprises three domains; the N-terminal, guanine nucleotide-binding (G domain), and C-terminal domains. Structural domains comprising this superfamily share the structure of the N-terminal domain, also known as the GTP1/OBG domain as it presents the OBG fold, formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich. These regions form six left-handed collagen-like helices packed and H-bonded together.

GTP-binding proteins such as the murine DRG protein, GTP1 protein from Schizosaccharomyces pombe, OBG protein from Bacillus subtilis contain characteristic GTP-binding motifs and are similar to each other, but they do not share sequence similarity to other GTP-binding proteins, and have therefore been classed as a novel group, the GTP1/OBG family. For now, the functions of these proteins is uncertain, but they have been shown to be important in development and normal cell metabolism PMID:8462872,PMID:2537815.

GO Diversity

Unique GO annotations
37 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
13760 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC:
Unique GO: 37
Unique Species: 13760