The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1134
3D
6d6uD01 - 84.5
2
891
3D
5vdiE01 - 76.7
3
734
3D
6d6uE01 - 93.6
4
717
3D
5ojmE01 - 71.8
5
659
3D
5fjvE00 - 91.6
6
419 - - 80.3
7
360 - - 81.0
8
345 - - 77.5
9
322 - - 79.6
10
272
3D
6hy7A00 - 77.9
12
260
3D
2bg9E01 - 93.5
11
258 - - 84.5
13
237 - - 91.3
14
236 - - 92.5
15
218 - - 52.8
17
218
3D
6hiqE01 - 93.3
16
216 - - 94.9
18
GABA-A
196 - - 62.6
19
187
3D
5hbvB00 - 85.3
20
164 - - 25.6
21
161 - - 92.9
143
157
3D
6d1sJ01 - 2.8
95
134
3D
6hzwE01 - 65.9
22
125 - - 78.1
23
86 - - 75.2
24
85 - - 70.4
38
73
3D
4tnwT01 - 82.2
25
68 - - 31.0
26
61 - - 80.7
27
58 - - 93.7
28
52 - - 90.5
29
51 - - 38.5
30
49 - - 89.1
31
47 - - 88.2
32
46 - - 44.5
33
GABA-A
43 - - 47.4
34
40 - - 81.2
35
38 - - 79.9
36
37 - - 40.4
37
34 - - 78.4
39
30 - - 70.6
40
29 - - 86.3
41
27 - - 87.4
43
25 - - 70.5
42
25 - - 92.8
44
25 - - 89.8
45
22 - - 96.6
46
21 - - 12.1
47
20 - - 44.8
48
19 - - 9.8
49
17 - - 52.2
50
17 - - 27.1
51
16 - - 65.6
52
15 - - 59.8
53
15 - - 96.7
55
13 - - 61.4
57
13 - - 95.7
56
13 - - 85.5
54
13 - - 35.3
58
12 - - 26.6
160
12
3D
4afhE00 - 0.6
60
12 - - 96.3
59
12 - - 0.0
62
11 - - 8.4
61
11 - - 28.6
64
11 - - 91.9
65
11 - - 96.2
63
11 - - 74.4
67
9 - - 12.4
68
9 - - 82.2
66
9 - - 28.8
71
8 - - 77.5
73
8 - - 89.1
74
8 - - 94.3
69
8 - - 14.0
72
8 - - 90.7
70
8 - - 8.5
76
7 - - 58.1
77
7 - - 16.4
83
7 - - 8.9
78
7 - - 9.2
81
7 - - 28.1
82
7 - - 80.3
79
7 - - 69.9
80
7 - - 4.1
75
7 - - 94.8
84
6 - - 12.1
87
6 - - 77.1
86
6 - - 21.8
85
6 - - 5.6
90
5 - - 16.4
89
5 - - 75.5
91
5 - - 37.4
92
5 - - 3.5
88
5 - - 11.7
102
4 - - 66.8
93
4 - - 21.3
101
4 - - 32.0
104
4 - - 64.3
96
4 - - 5.4
98
4 - - 7.7
103
4 - - 68.8
107
4 - - 77.0
97
4 - - 8.4
100
4 - - 3.8
94
4 - - 70.8
106
4 - - 82.6
99
4 - - 62.5
105
4 - - 75.2
118
3 - - 4.2
114
3 - - 6.1
124
3 - - 43.5
119
3 - - 11.9
115
3 - - 36.0
113
3 - - 70.0
116
exons 5-10 exons A-E
3 - - 3.9
120
3 - - 54.8
122
3 - - 43.9
125
3 - - 81.0
109
3 - - 37.3
110
3 - - 60.2
112
3 - - 74.9
121
3 - - 69.9
117
3 - - 19.7
108
3 - - 25.7
123
3 - - 73.1
111
3 - - 31.3
127
2 - - 34.2
163
2 - - 36.7
175
2 - - 42.7
153
2 - - 36.5
139
2 - - 0.5
129
2 - - 33.6
168
2 - - 44.2
135
2 - - 43.2
145
2 - - 4.7
178
2 - - 45.0
140
2 - - 4.3
131
2 - - 35.4
181
2 - - 39.7
154
2 - - 38.5
159
2 - - 0.5
180
2 - - 40.0
162
2 - - 19.9
152
neuronal CHRNB2
2 - - 0.0
174
2 - - 43.6
136
2 - - 43.0
144
2 - - 0.0
177
2 - - 43.9
158
2 - - 40.2
169
2 - - 43.0
132
2 - - 37.6
171
2 - - 38.1
161
2 - - 4.9
151
2 - - 0.0
148
2 - - 4.7
157
2 - - 40.3
138
2 - - 0.0
137
2 - - 43.6
165
2 - - 3.1
147
2 - - 6.6
172
2 - - 41.6
126
2 - - 13.9
176
2 - - 47.8
170
2 - - 44.4
179
2 - - 45.6
182
2 - - 24.5
142
2 - - 0.0
167
2 - - 36.4
133
2 - - 41.5
149
2 - - 0.0
173
2 - - 40.7
166
2 - - 36.9
141
2 - - 0.0
128
2 - - 33.1
134
2 - - 45.4
156
2 - - 39.1
150
2 - - 0.0
130
2 - - 33.0
155
2 - - 38.6
146
2 - - 5.8
164
2 - - 41.5
276
1 - - 0.0
206
1 - - 0.0
233
1 - - 0.0
194
1 - - 0.0
259
1 - - 0.0
220
1 - - 0.0
208
1 - - 0.0
292
1 - - 0.0
291
1 - - 0.0
199
1 - - 0.0
226
1 - - 0.0
211
1 - - 0.0
241
1 - - 0.0
198
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
236
1 - - 0.0
218
1 - - 0.0
202
1 - - 0.0
249
1 - - 0.0
184
1 - - 0.0
285
1 - - 0.0
234
1 - - 0.0
307
1 - - 0.0
270
1 - - 0.0
195
1 - - 0.0
193
1 - - 0.0
288
1 - - 0.0
244
1 - - 0.0
240
1 - - 0.0
246
1 - - 0.0
230
1 - - 0.0
299
1 - - 0.0
201
1 - - 0.0
189
1 - - 0.0
295
1 - - 0.0
266
1 - - 0.0
214
1 - - 0.0
221
1 - - 0.0
302
1 - - 0.0
229
1 - - 0.0
260
1 - - 0.0
237
1 - - 0.0
309
1 - - 0.0
188
1 - - 0.0
222
1 - - 0.0
300
1 - - 0.0
286
1 - - 0.0
305
1 - - 0.0
308
1 - - 0.0
254
1 - - 0.0
217
1 - - 0.0
239
1 - - 0.0
205
1 - - 0.0
281
1 - - 0.0
269
1 - - 0.0
235
1 - - 0.0
301
1 - - 0.0
213
1 - - 0.0
183
1 - - 0.0
296
1 - - 0.0
265
1 - - 0.0
200
1 - - 0.0
272
1 - - 0.0
190
1 - - 0.0
298
1 - - 0.0
243
1 - - 0.0
231
1 - - 0.0
287
1 - - 0.0
294
1 - - 0.0
275
1 - - 0.0
197
1 - - 0.0
203
1 - - 0.0
261
1 - - 0.0
284
1 - - 0.0
247
1 - - 0.0
204
1 - - 0.0
289
1 - - 0.0
186
1 - - 0.0
228
1 - - 0.0
268
1 - - 0.0
191
1 - - 0.0
224
1 - - 0.0
187
1 - - 0.0
223
1 - - 0.0
282
1 - - 0.0
262
1 - - 0.0
212
1 - - 0.0
238
1 - - 0.0
251
1 - - 0.0
253
1 - - 0.0
279
1 - - 0.0
209
1 - - 0.0
216
1 - - 0.0
256
1 - - 0.0
227
1 - - 0.0
255
1 - - 0.0
264
1 - - 0.0
297
1 - - 0.0
277
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
263
1 - - 0.0
290
1 - - 0.0
304
1 - - 0.0
210
1 - - 0.0
258
1 - - 0.0
293
1 - - 0.0
274
1 - - 0.0
306
1 - - 0.0
252
1 - - 0.0
283
1 - - 0.0
250
1 - - 0.0
303
1 - - 0.0
192
1 - - 0.0
215
1 - - 0.0
278
1 - - 0.0
271
1 - - 0.0
245
1 - - 0.0
267
GABA
1 - - 0.0
219
1 - - 0.0
257
1 - - 0.0
185
1 - - 0.0
248
1 - - 0.0
196
1 - - 0.0
242
1 - - 0.0