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CATH Superfamily 2.70.170.10

Neurotransmitter-gated ion-channel ligand-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Gamma-aminobutyric acid A receptor subunit alpha-2
1134
3D
 6d6uD01 - 84.5
2
Glycine receptor alpha 1 subunit
891
3D
 5vdiE01 - 76.7
3
Putative gamma-aminobutyric acid receptor subunit gamma-2
734
3D
 6d6uE01 - 93.6
4
Gamma-aminobutyric acid receptor subunit beta-2 isoform A
717
3D
 5ojmE01 - 71.8
5
Neuronal nicotinic acetylcholine receptor alpha4 subunit
659
3D
 5fjvE00 - 91.6
6
Cholinergic receptor nicotinic beta 2 subunit
419 - - 80.3
7
Gamma-aminobutyric acid type A receptor rho2 subunit
360 - - 81.0
8
Cholinergic receptor nicotinic alpha 6 subunit
345 - - 77.5
9
Neuronal acetylcholine receptor subunit alpha-7
322 - - 79.6
10
neuronal acetylcholine receptor subunit alpha-9
272
3D
 6hy7A00 - 77.9
12
Nicotinic acetylcholine receptor subunit gamma
260
3D
 2bg9E01 - 93.5
11
Gamma-aminobutyric acid receptor subunit pi isoform X1
258 - - 84.5
13
Acetylcholine receptor subunit alpha
237 - - 91.3
14
Glycine receptor subunit beta
236 - - 92.5
15
gamma-aminobutyric acid receptor subunit rho-1 isoform X1
218 - - 52.8
17
5-hydroxytryptamine receptor 3A
218
3D
 6hiqE01 - 93.3
16
Nicotinic acetylcholine receptor subunit
216 - - 94.9
18
Gamma-aminobutyric acid
GABA-A
196 - - 62.6
19
Putative acetylcholine receptor subunit alpha
187
3D
 5hbvB00 - 85.3
20
glutamate-gated chloride channel isoform X12
164 - - 25.6
21
Gamma-aminobutyric acid receptor isoform 3b
161 - - 92.9
143
Gamma-aminobutyric-acid receptor subunit beta-1
157
3D
 6d1sJ01 - 2.8
95
Proton-gated ion channel
134
3D
 6hzwE01 - 65.9
22
glutamate-gated chloride channel isoform X1
125 - - 78.1
23
Acetylcholine receptor subunit beta-like 1
86 - - 75.2
24
Histamine-gated chloride channel subunit
85 - - 70.4
38
Glutamate-gated chloride channel alpha
73
3D
 4tnwT01 - 82.2
25
Gamma-aminobutyric acid type A receptor beta3 subunit
68 - - 31.0
26
5-hydroxytryptamine receptor 3C
61 - - 80.7
27
Ligand-Gated ion Channel
58 - - 93.7
28
AcetylCholine Receptor
52 - - 90.5
29
Cholinergic receptor nicotinic alpha 10 subunit
51 - - 38.5
30
AcetylCholine Receptor
49 - - 89.1
31
AcetylCholine Receptor
47 - - 88.2
32
Uncharacterized protein, isoform B
46 - - 44.5
33
Gamma-aminobutyric acid
GABA-A
43 - - 47.4
34
Ligand-Gated ion Channel
40 - - 81.2
35
Ligand-Gated ion Channel
38 - - 79.9
36
Gamma-aminobutyric acid receptor subunit beta-like
37 - - 40.4
37
zinc-activated ligand-gated ion channel
34 - - 78.4
39
Ligand-Gated ion Channel
30 - - 70.6
40
Cholinergic receptor nicotinic gamma subunit
29 - - 86.3
41
Acetylcholine receptor subunit gamma
27 - - 87.4
43
Gamma-aminobutyric acid receptor alpha-like
25 - - 70.5
42
Blast:Glycine receptor subunit alpha-3
25 - - 92.8
44
AcetylCholine Receptor
25 - - 89.8
45
Predicted protein
22 - - 96.6
46
Cholinergic receptor nicotinic alpha 1 subunit
21 - - 12.1
47
neuronal acetylcholine receptor subunit alpha-5 isoform X2
20 - - 44.8
48
Cholinergic receptor nicotinic alpha 1 subunit
19 - - 9.8
50
Nicotinic acetylcholine receptor alpha4, isoform D
17 - - 27.1
49
Ligand-Gated ion Channel
17 - - 52.2
51
Ligand-Gated ion Channel
16 - - 65.6
53
Predicted protein
15 - - 96.7
52
Ligand-Gated ion Channel
15 - - 59.8
54
Ligand-Gated ion Channel
13 - - 35.3
57
Ligand-Gated ion Channel
13 - - 95.7
56
Ligand-Gated ion Channel
13 - - 85.5
55
Proton-gated ion channel subunit pbo-6
13 - - 61.4
60
Nicotinic acetylcholine receptor subunit alpha4
12 - - 96.3
58
Ligand-gated chloride channel
12 - - 26.6
59
Uncharacterized protein, isoform F
12 - - 0.0
160
Achbp
12
3D
 4afhE00 - 0.6
64
Uncharacterized protein
11 - - 91.9
65
Glutamate-gated chloride channel, putative
11 - - 96.2
63
Ligand-Gated ion Channel
11 - - 74.4
62
Histamine-gated chloride channel subunit
11 - - 8.4
61
Ligand-gated ion channel 4
11 - - 28.6
67
Ligand-Gated ion Channel
9 - - 12.4
66
Glutamate-gated ChLoride channel
9 - - 28.8
68
LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like
9 - - 82.2
69
Acetylcholine-gated chloride channel subunit acc-1
8 - - 14.0
71
Nicotinic acetylcholine receptor Dalpha7 subunit
8 - - 77.5
72
Uncharacterized protein
8 - - 90.7
73
Uncharacterized protein
8 - - 89.1
70
Ligand-Gated ion Channel
8 - - 8.5
74
Uncharacterized protein
8 - - 94.3
78
Gamma-aminobutyric acid receptor subunit alpha-4
7 - - 9.2
81
Ligand-Gated ion Channel
7 - - 28.1
82
Uncharacterized protein
7 - - 80.3
83
AcetylCholine Receptor
7 - - 8.9
75
Uncharacterized protein
7 - - 94.8
76
Gamma-aminobutyric acid receptor subunit gamma-3
7 - - 58.1
77
Acetylcholine-gated chloride channel subunit acc-3
7 - - 16.4
80
Acetylcholine receptor subunit alpha-type unc-63
7 - - 4.1
79
Uncharacterized protein
7 - - 69.9
85
Probable ligand-gated ion channel 46
6 - - 5.6
86
NtR, isoform A
6 - - 21.8
87
Gamma-aminobutyric acid type A receptor alpha6 subunit
6 - - 77.1
84
Ligand-Gated ion Channel
6 - - 12.1
88
Ligand-Gated ion Channel
5 - - 11.7
90
gamma-aminobutyric acid receptor subunit rho-1-like isoform X2
5 - - 16.4
92
Gamma-aminobutyric acid type A receptor alpha6 subunit
5 - - 3.5
91
Gamma-aminobutyric acid type A receptor alpha2 subunit
5 - - 37.4
89
Uncharacterized protein
5 - - 75.5
103
Predicted protein
4 - - 68.8
105
Nicotinic acetylcholine receptor a9 subunit splice variant
4 - - 75.2
97
Uncharacterized protein, isoform D
4 - - 8.4
96
Gamma-aminobutyric acid receptor subunit beta
4 - - 5.4
101
Uncharacterized protein
4 - - 32.0
99
Gamma-aminobutyric acid type A receptor rho1 subunit
4 - - 62.5
94
Uncharacterized protein
4 - - 70.8
102
Predicted protein
4 - - 66.8
107
Uncharacterized protein
4 - - 77.0
104
Uncharacterized protein
4 - - 64.3
106
Si:ch211-39a7.1
4 - - 82.6
100
Protein CBR-LGC-28
4 - - 3.8
98
Neuronal acetylcholine receptor subunit alpha-9
4 - - 7.7
93
cDNA FLJ56966, highly similar to Gamma-aminobutyric-acid receptor alpha-5 subunit
4 - - 21.3
124
Uncharacterized protein
3 - - 43.5
120
Cholinergic receptor nicotinic epsilon subunit
3 - - 54.8
110
Uncharacterized protein
3 - - 60.2
114
Ligand-Gated ion Channel
3 - - 6.1
116
CHRNA7
exons 5-10 exons A-E
3 - - 3.9
118
AGAP010057-PA
3 - - 4.2
119
Acetylcholine receptor subunit alpha
3 - - 11.9
125
Uncharacterized protein
3 - - 81.0
123
Uncharacterized protein
3 - - 73.1
113
Gamma-aminobutyric acid type A receptor pi subunit
3 - - 70.0
115
Si:ch73-380n15.2
3 - - 36.0
117
GH14445p
3 - - 19.7
108
Ligand-Gated ion Channel
3 - - 25.7
122
Uncharacterized protein
3 - - 43.9
109
Uncharacterized protein
3 - - 37.3
121
Predicted protein
3 - - 69.9
111
Uncharacterized protein
3 - - 31.3
112
Uncharacterized protein
3 - - 74.9
126
Predicted protein
2 - - 13.9
130
Uncharacterized protein
2 - - 33.0
172
Uncharacterized protein
2 - - 41.6
171
Uncharacterized protein
2 - - 38.1
167
Uncharacterized protein
2 - - 36.4
157
CHRNA7-FAM7A fusion protein
2 - - 40.3
136
Uncharacterized protein
2 - - 43.0
134
Glutamate-gated chloride channel, putative
2 - - 45.4
145
Protein CBR-LGC-31
2 - - 4.7
151
Uncharacterized protein
2 - - 0.0
152
Macaca fascicularis brain cDNA clone: QflA-17345, similar to human cholinergic receptor, nicotinic, beta polypeptide 2
neuronal CHRNB2
2 - - 0.0
162
Neurotransmitter gated ion channel, putative
2 - - 19.9
161
Transmembrane ion channel
2 - - 4.9
177
Protein CBR-DEG-3
2 - - 43.9
129
Predicted protein
2 - - 33.6
175
Si:ch211-256e16.10
2 - - 42.7
173
Uncharacterized protein
2 - - 40.7
128
Uncharacterized protein
2 - - 33.1
141
gamma-aminobutyric acid receptor subunit beta-3-like
2 - - 0.0
139
Nicotinic acetylcholine receptor a10 subunit splice variant
2 - - 0.5
138
Transmembrane ion channel
2 - - 0.0
142
Transmembrane ion channel
2 - - 0.0
147
5-hydroxytryptamine receptor 3D
2 - - 6.6
153
Uncharacterized protein
2 - - 36.5
155
Nicotinic acetylcyoline receptor Dalpha 4 subunit
2 - - 38.6
165
Protein CBR-ACR-8
2 - - 3.1
163
Uncharacterized protein
2 - - 36.7
180
Protein CBG10414
2 - - 40.0
179
Uncharacterized protein
2 - - 45.6
178
Glycine receptor alpha 2
2 - - 45.0
140
Ligand-Gated ion Channel
2 - - 4.3
144
Transmembrane ion channel
2 - - 0.0
135
Uncharacterized protein
2 - - 43.2
133
Predicted protein
2 - - 41.5
146
Uncharacterized protein
2 - - 5.8
158
Predicted protein
2 - - 40.2
181
Neuronal acetylcholine receptor subunit alpha-3, putative
2 - - 39.7
182
Uncharacterized protein
2 - - 24.5
159
Transmembrane ion channel
2 - - 0.5
169
Nicotinic acetylcholine receptor alpha 9 subunit
2 - - 43.0
168
Protein CBR-ACR-8
2 - - 44.2
176
Uncharacterized protein
2 - - 47.8
174
Uncharacterized protein
2 - - 43.6
148
Ligand-Gated ion Channel
2 - - 4.7
170
Uncharacterized protein
2 - - 44.4
132
Uncharacterized protein
2 - - 37.6
131
Uncharacterized protein
2 - - 35.4
149
Nicotinic acetylcholine receptor subunit
2 - - 0.0
154
Uncharacterized protein
2 - - 38.5
137
Uncharacterized protein
2 - - 43.6
156
Uncharacterized protein
2 - - 39.1
166
Protein CBR-DEG-3
2 - - 36.9
164
Neurotransmitter gated ion channel, putative
2 - - 41.5
150
CHRNA7-FAM7A fusion protein
2 - - 0.0
127
Uncharacterized protein
2 - - 34.2
243
Uncharacterized protein
1 - - 0.0
293
Uncharacterized protein
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
257
Protein CBG01602
1 - - 0.0
295
Uncharacterized protein
1 - - 0.0
245
Cholinergic receptor, nicotinic, beta 2
1 - - 0.0
234
Uncharacterized protein
1 - - 0.0
230
Protein CBR-EXP-1
1 - - 0.0
203
Uncharacterized protein
1 - - 0.0
272
Predicted protein
1 - - 0.0
193
Uncharacterized protein
1 - - 0.0
226
Uncharacterized protein
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
205
Uncharacterized protein
1 - - 0.0
271
Uncharacterized protein
1 - - 0.0
195
Uncharacterized protein
1 - - 0.0
267
Gamma-aminobutyric acid
GABA
1 - - 0.0
188
AGAP009493-PA
1 - - 0.0
262
Predicted protein
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
216
Uncharacterized protein
1 - - 0.0
261
Uncharacterized protein
1 - - 0.0
277
Uncharacterized protein
1 - - 0.0
189
Uncharacterized protein
1 - - 0.0
303
Uncharacterized protein
1 - - 0.0
288
Si:ch211-39a7.1
1 - - 0.0
251
Soluble acetylcholine receptor
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
210
Uncharacterized protein
1 - - 0.0
305
Protein CBG01074
1 - - 0.0
289
Uncharacterized protein
1 - - 0.0
239
Predicted protein
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
307
Uncharacterized protein
1 - - 0.0
241
Uncharacterized protein
1 - - 0.0
292
Uncharacterized protein
1 - - 0.0
242
Cholinergic receptor, nicotinic alpha 9
1 - - 0.0
238
Uncharacterized protein
1 - - 0.0
191
Uncharacterized protein
1 - - 0.0
275
Uncharacterized protein
1 - - 0.0
229
Uncharacterized protein
1 - - 0.0
201
Uncharacterized protein
1 - - 0.0
273
SD10415p
1 - - 0.0
228
Uncharacterized protein
1 - - 0.0
202
Gamma-aminobutyric acid type A receptor alpha2 subunit a
1 - - 0.0
192
Predicted protein
1 - - 0.0
184
Uncharacterized protein
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
207
Gaba-gated chloride channel, putative
1 - - 0.0
218
Uncharacterized protein
1 - - 0.0
219
Protein CBR-PBO-6
1 - - 0.0
263
Acetylcholine receptor subunit delta
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
186
Predicted protein
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
284
Predicted protein
1 - - 0.0
297
Uncharacterized protein
1 - - 0.0
301
Uncharacterized protein
1 - - 0.0
247
Cholinergic receptor nicotinic beta 1 subunit
1 - - 0.0
302
Uncharacterized protein
1 - - 0.0
286
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
235
Uncharacterized protein
1 - - 0.0
287
Uncharacterized protein
1 - - 0.0
294
Cholinergic receptor, nicotinic, alpha 6
1 - - 0.0
244
Uncharacterized protein
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
233
Uncharacterized protein
1 - - 0.0
296
Protein CBG26995
1 - - 0.0
246
Uncharacterized protein
1 - - 0.0
190
Uncharacterized protein
1 - - 0.0
279
Uncharacterized protein
1 - - 0.0
187
Predicted protein
1 - - 0.0
194
Predicted protein
1 - - 0.0
225
Uncharacterized protein
1 - - 0.0
204
Predicted protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
290
Uncharacterized protein
1 - - 0.0
206
Predicted protein
1 - - 0.0
223
Uncharacterized protein
1 - - 0.0
278
Uncharacterized protein
1 - - 0.0
196
Uncharacterized protein
1 - - 0.0
213
Uncharacterized protein
1 - - 0.0
269
Uncharacterized protein
1 - - 0.0
300
Uncharacterized protein
1 - - 0.0
215
Uncharacterized protein
1 - - 0.0
268
Uncharacterized protein
1 - - 0.0
304
Uncharacterized protein
1 - - 0.0
258
Uncharacterized protein
1 - - 0.0
281
Uncharacterized protein
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
306
Protein CBG26995
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
270
Uncharacterized protein
1 - - 0.0
232
Uncharacterized protein
1 - - 0.0
298
Uncharacterized protein
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
299
Cholinergic receptor nicotinic alpha 10 subunit
1 - - 0.0
249
Cholinergic receptor nicotinic alpha 10 subunit
1 - - 0.0
231
Predicted protein
1 - - 0.0
276
Uncharacterized protein
1 - - 0.0
198
Uncharacterized protein
1 - - 0.0
222
Uncharacterized protein
1 - - 0.0
217
Uncharacterized protein
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
209
Uncharacterized protein
1 - - 0.0
199
Uncharacterized protein
1 - - 0.0
274
Predicted protein
1 - - 0.0
266
Predicted protein
1 - - 0.0
211
Glutamate-gated chloride channel, putative
1 - - 0.0
183
Predicted protein
1 - - 0.0
250
Nicotinic acetylcholine receptor subunit
1 - - 0.0
227
Uncharacterized protein
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
264
GABA receptor alpha 6 subunit
1 - - 0.0
260
Protein CBG24733
1 - - 0.0
283
Protein CBG01074
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
308
Uncharacterized protein
1 - - 0.0
285
Uncharacterized protein
1 - - 0.0
256
Uncharacterized protein
1 - - 0.0
309
Uncharacterized protein
1 - - 0.0
237
Glycine receptor alpha 1 variant, putative
1 - - 0.0
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