The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Zona pellucida, ZP-C domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Zona pellucida, ZP-C domain

The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C-terminus of many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer PMID:1313375,PMID:12021773,PMID:12878193,PMID:15079052.

The ZP module is not only conserved in egg coat components but is also found in many other secreted eukaryotic proteins with variable architecture and biological function. It is responsible for the incorporation of ZP3 and other subunits into the ZP and consists of two domains, ZP-N and ZP-C, that are separated by a protease-sensitive linker. Whereas ZP-N is thought to constitute a basic building block of ZP filaments, ZP-C may mediate the specificity of interaction between subunits. These processes are controlled by an external hydrophobic patch (EHP) contained within the C-terminal propeptide of ZP component precursors and an internal hydrophobic patch (IHP) inside the ZP module.

This superfamily entry represents the ZP-C domain.

DOI:10.1038/nature07599,DOI:10.1016/j.cell.2010.09.041, INTERPRO:IPR001507

GO Diversity

Unique GO annotations
217 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
579 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 8
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 5
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 31
Unique EC:
Unique GO: 217
Unique Species: 579