The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Reeler domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Reeler domain

This superfamily represents the reeler (reelin) domain, a ~170 amino acid module which has been identified in the extracellular matrix proteins reelin and F-spondin (renamed Spon1) PMID:18602404,PMID:19020352. F-spondin is a secreted and extracellular matrix-attached protein that has been implicated in axonal pathfinding during neural development as well as in vascular remodelling in adult tissues PMID:19020352. The reelin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1), the spondin domain, the fibronectin type III domain or the Kunitz trypsin protease inhibitor domain. Its function is not yet known PMID:9441663,PMID:10409509. Although some of these proteins are specifically expressed in neural tissues, no specific biological function has been attributed to this domain PMID:19020352.

The reeler domain of F-spondin is composed of four-stranded and five-stranded antiparallel beta-sheets that are arranged in a beta-sandwich fold.

PFAM:PF02014, INTERPRO:IPR002861,DOI:10.1107/S0907444908028308

GO Diversity

Unique GO annotations
102 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
591 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 8
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 17
Unique EC:
Unique GO: 102
Unique Species: 591