The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Cell-cell fusogen EFF/AFF, domain 3

Structural domains comprising this superfamily share the structure of domain 3 of the cell-cell fusogen EFF/AFF. This three domain proteins are involved in cell fusion, as their name indicates, process that is essential for development. This proteins can be found either as a monomer or trimer, crystal structures of the trimer show unambiguous structural homology to class II viral fusion proteins in their characteristic postfusion hairpin conformation. The trimer subunits feature the three class II beta sandwich domains, termed I, II, and III, organized in the same way as in the viral proteins PMID:24725407.

GO Diversity

Unique GO annotations
20 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
90 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO: 20
Unique Species: 90