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CATH Superfamily 2.60.40.2170

Wnt, WIF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Wnt, WIF domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Wnt, WIF domain

Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1WD) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands.

This superfamily entry represents the WIF domain, it is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt PMID:10637605. The WIF domain of WIF-1 was suggested to have a function in inhibiting Wnt signalling PMID:21743455.

INTERPRO:IPR003306, PFAM:PF02019,DOI:10.1038/nsmb.2081

GO Diversity

Unique GO annotations
82 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
374 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 5
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 19
Function
Unique EC: 1
Unique GO: 82
Taxonomy
Unique Species: 374
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