The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

YEATS domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: YEATS domain

Structural domains comprising this superfamily share the structure of the YEATS (Yaf9, ENL, AF9, Taf14, and Sas5) domain, an evolutionarily conserved module present in 4 proteins (ENL, AF9, GAS41, and YEATS2) in humans and 3 proteins (Sas5, Taf14, and Yaf9) in yeast. These proteins are found in major chromatin-remodeling and histone acetyl-transferase (HAT) complexes and implicated in regulation of chromatin structure, histone acetylation and deposition, gene transcription and DNA damage response. The YEATS domain, which as previously shown is found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation.The ability of the YEATS domains of human AF9 and yeast Taf14 to recognize the histone mark H3K9ac, have shown that these proteins are members of the family of acetyllysine readers PMID:27545619,PMID:27545619,PMID:26341557.

GO Diversity

Unique GO annotations
83 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1586 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 56
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 4
Unique PDBs: 32
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 12
Unique EC:
Unique GO: 83
Unique Species: 1586