The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Laminin, LN domain

Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. It is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components PMID:1975589. The polymerisation of laminin into a cell-associated network - a key step in basement membrane assembly - is mediated by the laminin amino-terminal (LN) domains at the tips of the three short arms of the laminin alpha-beta-gamma heterotrimer PMID:21311558.

Basement membrane assembly is a cooperative process in which laminins polymerise through their N-terminal domain (LN or domain VI) and anchor to the cell surface through their G domains. Netrins may also associate with this network through heterotypic LN domain interactions PMID:8349613. This leads to cell signalling through integrins and dystroglycan (and possibly other receptors) recruited to the adherent laminin. This LN domain dependent self-assembly is considered to be crucial for the integrity of basement membranes, as highlighted by genetic forms of muscular dystrophy containing the deletion of the LN module from the alpha 2 laminin chain PMID:7874173. The laminin N-terminal domain is found in all laminin and netrin subunits except laminin alpha 3A, alpha 4 and gamma 2.

INTERPRO:IPR008211,PFAM:PF00055

GO Diversity

Unique GO annotations
254 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
447 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 15
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 4
Unique PDBs: 12
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 4
Unique GO: 254
Taxonomy
Unique Species: 447