The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
This superfamily comprises the beta barrel domain and it is found in bacterial drug and metal resistance nodulation cell division (RND)-driven efflux pumps adaptor proteins, such as MexA (from MexAB-OprM efflux pump in Pseudomonas aeruginosa), BesA (from the spirochete Borrelia burgdorferi), CusA (from the CusCBA efflux system), ZneB (the membrane fusion protein component of the ZneCAB efflux complex), MacA (from MacAB-TolC pump), EmrA or AcrA (in E. coli, EmrAB-TolC and AcrA-AcrB-TolC). Structurally, this domain is a beta barrel composed of six to eight beta-strands, and it may contain an alpha-helix situated at entrance to the barrel. It has been suggested that this domain plays a role in binding efflux substrates.
|Domain clusters (>95% seq id):||12|
|Domain clusters (>35% seq id):||8|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|