The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ribosomal protein L14

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L14/L23

This superfamily entry consists of the ribosomal protein L14 found in the large subunit of the prokaryotic, mitochondrial and plastid ribosome. The eukaryotic homologue of L14 is L23. Based on sequence alignment, L14 has a significant homology to L30. L14 directly binds to 23S rRNA.

The structure of L14 comprises a five-stranded beta-barrel, a C-terminal loop region that contains two small alpha-helices, and a beta-ribbon that projects from the beta-barrel. An analysis of the structure and the conserved amino acids reveals three surface patches that probably mediate L14-RNA and L14-protein interactions within the ribosome. As a ribosomal protein, L14 has a role in the folding and stabilisation of ribosomal RNA, binding RNA at two sites (RNA-binding site 1 at the N-terminus and RNA-binding site 2 at the C-terminus). One RNA-binding site appears to recognise a distinct region of ribosomal RNA during particle assembly. The second site is smaller and may become occupied during the later compaction of the RNA. The surface hydrophobic patch is a likely site of protein-protein interaction (the protein-binding site), possibly with L19.

INTERPRO:IPR036853, PFAM:PF00238,PMID:15299380,PMID:8805509

GO Diversity

Unique GO annotations
64 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
22545 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 405
Domain clusters (>95% seq id): 16
Domain clusters (>35% seq id): 3
Unique PDBs: 405
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 33
Unique EC:
Unique GO: 64
Unique Species: 22545