The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1939
3D
5jxbC00 - 94.9
2
1330
3D
3rl7F00 - 90.7
3
1279
3D
2cssA00 - 87.2
4
1138 - - 93.7
5
1136
3D
1ueqA00 - 97.5
6
1124
3D
1uepA00 - 82.2
7
1017
3D
1y7nA00 - 92.3
8
997
3D
3ps4D00 - 94.6
9
977
3D
3cyyB01 - 89.6
10
962 - - 83.3
11
931 - - 83.9
12
861 - - 85.6
13
848
3D
4q2qA00 - 84.0
14
823
3D
2mx6A00 - 87.3
15
765
3D
3bpuA00 - 89.4
16
758
3D
1kwaB00 - 74.2
17
756
3D
1x45A01 - 88.2
18
746 - - 87.9
19
744
3D
2uzcE00 - 86.1
20
723 - - 80.8
21
654
3D
2qt5B01 - 89.9
22
654
3D
1v5qA00 - 74.5
23
638
3D
2jilB00 - 94.8
24
606 - - 71.3
26
595
3D
4reyA02 - 95.4
25
591
3D
1p1dA02 - 74.2
27
571 - - 48.2
28
548
3D
1wh1A01 - 92.7
29
532 - - 76.5
30
527
3D
2lc6A00 - 73.7
32
523
3D
3axaB00 - 77.6
31
523
3D
1v62A00 - 90.9
33
GEF
514
3D
5tytD00 - 80.1
34
504
3D
1n7fB00 - 69.1
35
499
3D
1m5zA00 - 85.4
36
480
3D
3ch8A01 - 77.0
37
469
3D
3ou0A03 - 99.0
43
398
3D
4z33B02 - 97.2
38
388
3D
2dm8A00 - 81.9
45
386
3D
6hksF00 - 82.6
39
380 - - 68.6
40
379 - - 53.6
41
379
3D
5wouA00 - 86.9
44
374
3D
2dazA01 - 61.3
42
373
3D
2r4hC01 - 80.6
49
370
3D
4oajA00 - 71.4
50
360
3D
3ou0A04 - 91.0
46
358
3D
3o46A00 - 77.6
47
353
3D
2e7kA00 - 76.4
48
349 - - 77.6
52
348
3D
4hopE00 - 78.4
51
343
3D
2ehrA00 - 80.7
53
335 - - 71.0
55
333
3D
4q2oF00 - 95.5
56
333
3D
4reyA01 - 84.8
54
329
3D
2db5A00 - 74.2
57
317 - - 71.0
58
316
3D
2qg1A00 - 74.4
67
307
3D
4q6sB00 - 74.4
61
294
3D
3qe1A00 - 66.5
65
287
3D
4z33B01 - 90.0
59
287 - - 95.8
60
286 - - 87.3
62
284
3D
5f3xC02 - 87.8
63
280 - - 96.9
64
275
3D
4wyuB02 - 80.0
68
Na
+ +
271
3D
4q3hB00 - 84.2
66
263
3D
2yuyA00 - 64.3
73
257
3D
6bjoB00 - 88.9
77
255
3D
3gdvC03 - 29.2
69
253
3D
4hopF00 - 83.1
74
249
3D
5vwiB00 - 84.2
71
248
3D
2kbsA00 - 67.6
70
248
3D
2d92A00 - 86.4
72
245 - - 58.5
75
242
3D
2csjA00 - 76.8
78
236
3D
2kohA00 - 79.4
76
236 - - 57.5
79
232
3D
1ufxA00 - 92.1
80
228 - - 79.7
86
225
3D
3pdzA00 - 72.4
81
224 - - 80.5
82
223
3D
2yubA01 - 73.0
83
219 - - 75.1
84
218 - - 76.9
85
214 - - 79.4
87
206
3D
1uf1A00 - 91.5
88
206
3D
1va8A01 - 77.7
89
204
3D
2iwpB00 - 69.8
91
198
3D
3zrtD02 - 77.7
90
193 - - 94.7
92
189
3D
2eehA00 - 80.2
94
186
3D
3id1A00 - 39.4
95
186
3D
3id4A00 - 67.4
93
186
3D
2iwnA00 - 61.9
97
179
3D
3ggeC00 - 93.1
96
178
3D
1wi2A00 - 49.2
98
177
3D
2f5yB00 - 39.3
99
175
3D
3qikA01 - 76.1
100
175
3D
2edpA01 - 83.3
101
166 - - 70.3
102
166 - - 74.3
104
163
3D
1v6bA00 - 74.7
105
161
3D
5gljD00 - 77.4
103
161 - - 92.9
112
156
3D
4q2nF00 - 76.4
106
155 - - 73.9
107
155
3D
4o06A00 - 97.4
110
154
3D
2fneC00 - 60.6
108
153 - - 54.6
109
151 - - 75.6
111
150
3D
1uezA00 - 83.6
113
149
3D
1wfvA01 - 57.9
114
143
3D
1whaA01 - 79.4
115
132
3D
2kv8A00 - 58.0
120
131
3D
3vqgA00 - 81.9
116
130 - - 68.0
121
130
3D
4nnlB00 - 86.6
117
129 - - 72.5
118
127 - - 49.1
119
126 - - 50.6
122
123
3D
1x6dA01 - 81.5
123
Na
+ +
118 - - 83.0
124
115 - - 37.6
125
113
3D
2dluA00 - 83.6
127
108 - - 85.3
126
108 - - 40.1
128
105 - - 49.3
129
103 - - 61.9
130
mystique
103
3D
1vb7A00 - 73.6
131
96
3D
3soeA00 - 74.8
132
94 - - 29.5
133
94
3D
1uhpA00 - 85.7
134
93
3D
1wi4A01 - 47.9
135
92
3D
2eaqA00 - 31.8
136
90 - - 72.7
137
89 - - 88.1
145
89
3D
5wynA03 - 67.4
138
89 - - 49.8
142
86
3D
2ytwA00 - 75.7
139
86 - - 70.1
140
85 - - 48.3
141
84 - - 76.6
143
82 - - 77.4
144
80
3D
1ujvA00 - 90.6
154
79
3D
4gvdB00 - 44.5
147
79
3D
5fb8C00 - 85.9
148
77 - - 56.0
157
77
3D
2pntB00 - 81.2
146
77 - - 73.6
150
77
3D
1uewA00 - 81.4
170
76
3D
4yyxB00 - 56.1
149
76 - - 64.8
152
73
3D
1uitA00 - 85.1
151
73 - - 26.1
153
71 - - 72.6
155
70 - - 79.6
156
70
3D
1um1A00 - 58.3
161
69
3D
2jinA00 - 86.4
160
69
3D
2vsvB00 - 91.2
158
Predicted
68 - - 28.8
159
67 - - 45.6
162
65 - - 32.0
165
64
3D
2z17A00 - 76.0
163
64 - - 51.6
164
63 - - 76.3
166
Na
+ +
63
3D
2edzA01 - 45.8
168
62
3D
2edvA00 - 80.4
167
61 - - 65.0
169
61 - - 53.2
171
58 - - 77.1
174
57 - - 55.2
173
57 - - 76.8
172
57 - - 74.5
175
56 - - 40.0
176
56 - - 40.1
181
52
3D
4ri0A02 - 38.4
177
52 - - 76.4
178
51 - - 14.1
180
50 - - 30.1
179
50 - - 24.5
221
48
3D
1n6fF04 - 97.7
183
46 - - 86.6
182
46 - - 25.3
187
Na
+ +
45
3D
2eeiA00 - 53.2
184
45 - - 82.3
186
45 - - 22.9
185
45 - - 22.9
188
44 - - 41.6
189
44 - - 28.1
190
43 - - 16.3
191
42 - - 5.6
192
42 - - 81.7
211
Na
+ +
41
3D
6eziA00 - 52.2
193
41 - - 84.6
195
40 - - 13.7
194
40 - - 46.0
198
39
3D
3b76B00 - 70.6
196
39 - - 31.0
202
38
3D
3qo6C03 - 27.7
197
38 - - 84.5
207
37
3D
6ieoA03 - 36.6
199
Na
+ +
36 - - 39.3
200
35 - - 83.9
203
35 - - 97.8
204
35 - - 53.2
201
35 - - 18.7
205
34 - - 18.4
206
34 - - 86.5
209
33 - - 32.7
210
33 - - 73.0
208
33 - - 0.0
212
31 - - 17.1
213
31 - - 2.4
214
30 - - 29.5
215
28 - - 75.9
216
28 - - 12.8
217
26 - - 10.4
218
26 - - 29.4
219
25 - - 76.5
220
25 - - 5.2
222
23 - - 15.3
223
23 - - 24.9
224
22 - - 31.8
225
21 - - 64.9
227
21 - - 43.7
226
21 - - 50.1
232
20 - - 79.1
229
20 - - 23.4
228
20 - - 53.2
238
20
3D
1ihjB00 - 22.0
230
20 - - 20.1
231
Zonula Occludens tight junctional protein
20 - - 21.1
284
19
3D
6ireB02 - 15.4
233
19 - - 75.9
236
19 - - 10.9
234
19 - - 12.0
237
Actin filament binding protein
19 - - 61.8
235
19 - - 24.7
242
17 - - 21.9
293
17
3D
3r0hH01 - 14.6
243
17 - - 17.9
240
17 - - 26.4
239
17 - - 21.1
241
17 - - 7.6
246
16 - - 53.4
247
16 - - 19.7
248
16 - - 5.8
249
16 - - 64.1
244
16 - - 18.8
245
16 - - 10.6
252
Membrane Associated Guanylate kinase Inverted
15 - - 43.5
250
15 - - 26.6
251
15 - - 60.3
257
14 - - 8.1
254
14 - - 69.5
253
14 - - 15.1
258
14 - - 70.9
260
14 - - 44.5
255
14 - - 10.8
259
14 - - 39.1
363
14
3D
3pv2D03 - 0.0
256
14 - - 7.7
262
13 - - 52.4
263
13 - - 8.8
264
13 - - 5.9
274
13
3D
5f67B00 - 18.5
324
Serine proteinase MTB32B
13
3D
2z9iC03 - 15.1
261
13 - - 11.7
271
12 - - 67.1
267
12 - - 44.6
268
12 - - 50.6
269
12 - - 7.9
265
12 - - 17.5
270
12 - - 69.6
266
12 - - 2.9
272
11 - - 62.1
278
11 - - 6.6
281
11 - - 99.6
279
11 - - 35.0
280
11 - - 19.6
273
11 - - 10.1
276
11 - - 14.9
275
11 - - 21.4
282
11 - - 13.6
277
11 - - 74.2
285
10 - - 74.6
289
10 - - 90.8
288
10 - - 88.2
287
10 - - 4.4
283
10 - - 3.1
286
10 - - 10.3
301
9
3D
1v5lA00 - 61.1
294
9 - - 46.1
299
Membrane Associated Guanylate kinase Inverted
9 - - 9.9
290
9 - - 31.7
298
9 - - 48.2
297
9 - - 7.0
331
9
3D
4ic6C03 - 18.9
295
9 - - 42.1
300
9 - - 49.0
296
9 - - 11.8
292
9 - - 2.6
291
9 - - 20.0
311
8 - - 14.6
308
8 - - 13.1
307
8 - - 8.1
305
8 - - 4.5
309
8 - - 5.7
310
8 - - 0.0
314
8 - - 84.5
302
8 - - 31.5
303
8 - - 14.4
313
Membrane Associated Guanylate kinase Inverted
8 - - 12.8
312
8 - - 85.2
352
8
3D
3dpmB02 - 0.0
304
8 - - 0.0
306
8 - - 0.9
323
7 - - 8.9
326
7 - - 49.0
315
7 - - 69.1
317
7 - - 16.4
319
7 - - 10.7
322
7 - - 41.3
316
7 - - 13.6
318
7 - - 22.5
325
7 - - 0.0
320
7 - - 32.4
321
7 - - 32.2
330
6 - - 0.0
329
6 - - 0.0
333
6 - - 42.9
328
Protein4.1-ezrin-radixin-moesin
6 - - 14.6
332
6 - - 11.6
327
6 - - 76.2
350
Membrane Associated Guanylate kinase Inverted
5 - - 15.2
340
5 - - 0.0
366
5
3D
3hvqC01 - 37.5
349
5 - - 0.0
335
Mammalian Na/H Exchange Regulatory Factor
5 - - 3.2
344
5 - - 13.3
336
5 - - 0.0
351
5 - - 8.8
342
5 - - 8.3
341
5 - - 0.0
346
5 - - 7.5
334
5 - - 18.9
339
GRASP homologue
5 - - 42.8
345
5 - - 0.0
337
5 - - 0.0
347
5 - - 10.0
338
5 - - 32.4
348
5 - - 14.6
343
5 - - 7.6
359
GRASP homologue
4 - - 12.6
360
4 - - 22.1
353
4 - - 25.6
361
4 - - 12.9
365
4 - - 45.7
367
4 - - 39.0
354
4 - - 9.4
355
4 - - 7.1
362
4 - - 42.5
356
4 - - 1.8
357
4 - - 69.4
470
4
3D
5t69A02 - 0.0
358
4 - - 19.6
364
4 - - 10.9
370
4 - - 76.7
369
4 - - 75.8
368
4 - - 94.6
391
3 - - 44.1
375
3 - - 12.9
387
3 - - 10.5
383
3 - - 19.8
382
3 - - 7.7
386
3 - - 0.0
372
3 - - 64.0
376
3 - - 64.8
371
3 - - 2.8
378
3 - - 10.0
389
3 - - 1.5
381
3 - - 67.9
373
3 - - 51.2
385
3 - - 0.0
377
3 - - 0.0
390
3 - - 68.2
388
3 - - 40.1
379
3 - - 0.0
380
3 - - 0.0
374
3 - - 3.4
384
3 - - 42.9
463
2 - - 46.0
458
2 - - 2.0
486
2 - - 43.7
444
2 - - 46.2
456
2 - - 0.0
468
2 - - 9.0
413
2 - - 0.0
432
2 - - 2.7
477
2 - - 0.0
449
2 - - 0.0
490
2 - - 45.1
461
2 - - 11.0
425
2 - - 10.4
395
2 - - 6.1
412
2 - - 13.5
440
2 - - 38.9
467
2 - - 8.5
481
2 - - 0.0
474
2 - - 5.5
472
2 - - 0.0
457
2 - - 7.8
419
2 - - 50.7
406
2 - - 0.0
421
2 - - 16.5
408
2 - - 0.0
443
2 - - 0.0
431
2 - - 30.4
453
2 - - 5.5
488
2 - - 46.9
405
2 - - 0.0
392
2 - - 45.1
399
2 - - 0.0
436
2 - - 3.9
427
2 - - 9.3
426
2 - - 0.0
483
2 - - 0.0
414
2 - - 0.0
462
2 - - 0.0
476
2 - - 0.0
469
2 - - 0.0
471
2 - - 0.0
423
2 - - 0.0
422
2 - - 0.0
402
2 - - 34.8
464
2 - - 0.0
439
2 - - 34.1
407
2 - - 11.1
435
2 - - 45.5
487
2 - - 0.0
448
2 - - 3.6
396
2 - - 1.1
482
2 - - 41.4
450
2 - - 0.0
473
2 - - 0.0
451
2 - - 0.0
454
2 - - 6.1
410
2 - - 0.0
430
2 - - 0.0
447
2 - - 43.3
415
2 - - 4.9
480
2 - - 0.0
438
2 - - 0.0
417
2 - - 12.3
400
2 - - 0.0
475
2 - - 0.0
446
2 - - 40.1
393
2 - - 40.1
424
2 - - 0.0
434
2 - - 8.8
442
2 - - 39.8
465
2 - - 0.0
479
2 - - 1.2
484
2 - - 26.6
397
2 - - 6.5
459
2 - - 0.0
401
2 - - 11.8
404
2 - - 21.0
455
2 - - 7.6
437
2 - - 0.0
418
2 - - 28.7
485
2 - - 31.3
460
2 - - 4.8
452
2 - - 5.5
416
2 - - 0.0
445
2 - - 45.5
441
2 - - 40.6
428
2 - - 12.6
394
2 - - 0.0
429
2 - - 0.0
409
2 - - 4.4
489
2 - - 45.7
433
2 - - 0.0
411
2 - - 10.6
478
2 - - 0.0
398
2 - - 0.0
420
2 - - 48.0
403
2 - - 34.4
466
2 - - 0.0
512
1 - - 0.0
517
1 - - 0.0
495
1 - - 0.0
569
1 - - 0.0
536
1 - - 0.0
508
1 - - 0.0
558
1 - - 0.0
573
1 - - 0.0
638
1 - - 0.0
506
1 - - 0.0
581
1 - - 0.0
652
1 - - 0.0
606
1 - - 0.0
545
1 - - 0.0
588
1 - - 0.0
542
1 - - 0.0
574
1 - - 0.0
526
1 - - 0.0
566
1 - - 0.0
604
1 - - 0.0
501
1 - - 0.0
626
1 - - 0.0
539
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
584
1 - - 0.0
649
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
554
1 - - 0.0
552
1 - - 0.0
563
1 - - 0.0
546
1 - - 0.0
537
1 - - 0.0
529
1 - - 0.0
636
1 - - 0.0
600
1 - - 0.0
505
1 - - 0.0
625
1 - - 0.0
570
1 - - 0.0
655
1 - - 0.0
491
1 - - 0.0
597
1 - - 0.0
559
1 - - 0.0
580
1 - - 0.0
653
1 - - 0.0
509
1 - - 0.0
523
1 - - 0.0
595
1 - - 0.0
507
1 - - 0.0
644
1 - - 0.0
568
1 - - 0.0
525
1 - - 0.0
650
1 - - 0.0
498
1 - - 0.0
629
1 - - 0.0
533
1 - - 0.0
615
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
543
1 - - 0.0
603
1 - - 0.0
565
1 - - 0.0
511
1 - - 0.0
502
1 - - 0.0
553
1 - - 0.0
555
1 - - 0.0
647
1 - - 0.0
593
1 - - 0.0
641
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
562
1 - - 0.0
599
1 - - 0.0
609
1 - - 0.0
587
1 - - 0.0
624
1 - - 0.0
656
1 - - 0.0
596
1 - - 0.0
613
1 - - 0.0
494
1 - - 0.0
547
1 - - 0.0
631
1 - - 0.0
499
1 - - 0.0
528
1 - - 0.0
560
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
540
1 - - 0.0
571
1 - - 0.0
594
1 - - 0.0
586
1 - - 0.0
493
1 - - 0.0
534
1 - - 0.0
633
1 - - 0.0
515
1 - - 0.0
519
1 - - 0.0
646
1 - - 0.0
556
1 - - 0.0
510
1 - - 0.0
658
1 - - 0.0
549
1 - - 0.0
614
1 - - 0.0
583
1 - - 0.0
591
1 - - 0.0
619
1 - - 0.0
621
1 - - 0.0
524
1 - - 0.0
598
1 - - 0.0
602
1 - - 0.0
612
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