The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Major Vault Protein repeat

According to available literature structural domains comprising this superfamily share the structure of the Major Vault Protein repeat. Vaults are one of the largest cytoplasmic ribonucleoprotein particles, found in numerous eukaryotic species. The cellular function carried out by this ribonucleoproteins remains unclear, although roles in multidrug resistance and innate immunity have been suggested PMID:19150846. The primary sequence of MVP consists of seven short sequence repeats of ~55 amino acid residues followed by a central region and a coiled-coil protein association domain, which mediates the interactions between MVP molecules PMID:16373071.

GO Diversity

Unique GO annotations
27 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
295 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 74
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 3
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO: 27
Unique Species: 295