The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

CCR4-NOT complex subunit 2/3/5, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CCR4-NOT complex subunit 2/3/5, C-terminal domain

The Ccr4-Not complex is a large assembly involved in the regulation of eukaryotic gene expression at multiple levels. The best-studied function of Ccr4-Not relates to its action as the major deadenylase involved in shortening the poly(A) tail of cellular mRNAs in the cytoplasm PMID:24121231. The conserved core of the CCR4-NOT complex consists of two major modules: a catalytic module comprising two deadenylases (CAF1 or its paralogue POP2, and CCR4a or its paralogue CCR4b) and the NOT module, which minimally consists of NOT1, NOT2 and NOT3 PMID:22027279.

This entry represents the C-terminal domain of subunits 2, 3 and 5 of the complex. The C-terminal regions of NOT2 and NOT3 contain a conserved SH3-like NOT-box domain which mediates NOT-module assembly PMID:24121232.

GO Diversity

Unique GO annotations
44 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1536 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 24
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 6
Unique PDBs: 6
Structural Clusters (5A): 4
Structural Clusters (9A): 4
FunFam Clusters: 56
Unique EC:
Unique GO: 44
Unique Species: 1536