The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Zn-binding ribosomal proteins

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein S27

This superfamily includes the a zinc-binding domain found in the ribosomal protein S27 from the small (30S) subunit of the ribosome. Structurally it is a beta-sandwich, composed of two three-stranded sheets. The human S27 has an N-terminal extension relative to the archaeal S27. This a novel fold due to the uniqueness of the strands arrangement. Highly conserved residues forming a hydrophobic patch are supposed to have a functional importance. S27 is involved in rRNa processing, direct binding to mRNA and degradation of damaged mRNAs. S27 is a C4 zinc finger protein of the CX2CX14-16CX2C class. Zinc finger motifs in ribosomal proteins mediate protein-RNA interactions, however it has been suggested the zinc finger in S27 possibly has no functional importance for modern S27 proteins, and is rather a fossil from ancient evolution. This view is supported by the sequence alignment, showing that the zinc finger motif is not strictly conserved.

PFAM:PF01667, INTERPRO:IPR023407,PMID:15096641

GO Diversity

Unique GO annotations
42 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2192 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 68
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 3
Unique PDBs: 68
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Unique EC:
Unique GO: 42
Unique Species: 2192