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CATH Superfamily 2.10.70.80

Sortilin Vps10-D, 10CC-a domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sortilin Vps10-D, 10CC-a domain

Sortilin, also known as neurotensin receptor 3 (NTS3 or NTR3), is a multifunctional receptor belonging to the Vps10 domain family, or sortilins family. It is involved in cell sorting and apoptosis PMID:24985322. It is defined by a unique Vps10-domain (VPS10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin. Vps10-D consists of three structural domains: The N-terminal domain which is a ten-bladed beta-propeller structure followed by two cysteine rich 10CC-a and 10CC-b domains, which form the 10CC module. The 10CC domains have a low content of secondary structure and both interact extensively with the propeller PMID:19122660. This entry represents the 10CC-a domain.

PMID:24985322 PMID:19122660

GO Diversity

Unique GO annotations
111 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1121 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 20
Function
Unique EC:
Unique GO: 111
Taxonomy
Unique Species: 1121