Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Structural Representative PDB Sites? Alignment Diversity (0-100)
45768
20352 1bf9A00 - 88.2
45808
9783 2mhpA00 - 83.0
45878
8511 1autL02 - 96.0
45828
7542 - - 93.8
45855
4770 - - 94.0
13788
2113 - - 95.8
46367
1852 - - 94.3
45778
1799 1hj7A02 - 76.8
46294
1574 - - 79.0
45840
1566 - - 95.2
45893
1529 - - 71.0
46389
1525 - - 82.7
45630
1403 - - 77.2
45522
1375 - - 95.9
46116
1297 - - 83.5
46586
1297 1l3yA00 - 79.7
46267
1278 1jv2B03 - 95.5
45677
1228 - - 90.5
45944
1163 1gk5A00 - 92.6
45787
1097 - - 93.1
45737
1090 - - 94.8
45056
1080 - - 86.9
45457
1052 - - 87.7
45692
1028 - - 93.3
46239
Predicted
1013 3fcsD05 - 96.3
45554
983 - - 91.8
1350
961 - - 94.7
45628
913 - - 96.5
45609
901 - - 80.7
45473
896 - - 93.8
45463
886 - - 92.9
46248
809 - - 91.0
45095
791 1kloA02 - 96.5
45459
764 1hj7A01 - 60.1
46204
710 - - 90.7
45708
692 - - 87.1
45449
681 - - 88.1
46254
673 - - 74.1
45295
667 - - 80.9
46379
640 - - 87.1
45346
636 - - 95.3
46362
626 - - 93.8
45171
625 1yo8A02 - 85.1
45709
621 - - 91.2
45704
608 - - 94.1
46371
586 - - 89.9
45696
586 - - 93.1
46212
564 - - 69.1
44517
557 - - 95.2
45614
541 - - 75.9
45051
539 - - 66.5
45794
535 - - 90.6
11883
534 - - 76.5
45507
507 - - 95.3
45510
493 - - 71.4
46270
491 - - 66.8
45927
490 1yo8A01 - 88.2
45209
489 - - 90.5
45430
482 - - 80.3
44147
471 - - 88.2
45680
470 - - 84.2
46374
466 - - 89.7
45035
465 - - 88.0
45117
462 4aqtA02 - 88.3
46345
455 - - 97.3
45470
428 - - 88.2
46337
423 4d90A01 - 89.0
45575
422 - - 89.4
44386
419 - - 91.2
45622
415 - - 95.6
34856
412 - - 29.2
45671
398 - - 93.1
45627
390 - - 78.8
45129
388 - - 86.6
43766
387 - - 73.0
46208
386 - - 84.8
45093
377 - - 74.1
45084
370 1kloA01 - 90.4
44191
369 - - 86.2
45892
354 - - 76.4
21841
347 - - 83.7
45454
338 2p26A04 - 90.4
46176
333 - - 84.2
45898
326 - - 59.5
45771
323 - - 93.1
46275
322 1urkA01 - 84.3
45602
318 - - 81.4
45049
314 - - 74.9
44171
301 - - 89.0
45200
300 - - 74.1
44030
298 - - 59.5
45608
296 - - 87.6
45603
291 - - 88.8
45795
284 - - 89.5
45542
274 - - 57.0
44150
274 - - 77.3
5044
265 3zyjB01 - 73.2
45083
262 - - 91.9
46273
259 - - 81.3
45052
257 5f19A01 - 75.3
45157
257 - - 84.9
13753
250 - - 82.7
44139
250 - - 72.6
46459
250 - - 82.6
2338
245 - - 85.3
22070
240 3poyA03 - 52.8
45163
237 - - 76.2
43896
234 - - 71.1
43855
232 - - 68.7
46316
228 - - 92.3
432
220 - - 91.2
45615
218 - - 76.9
46274
217 - - 86.5
46238
216 - - 65.1
366
216 2w86A01 - 83.4
45278
213 - - 76.5
46403
204 - - 69.3
45373
202 - - 89.7
45126
195 - - 76.2
44597
194 - - 62.0
45464
192 1ijqA02 - 82.9
1757
190 - - 49.3
45600
188 - - 86.9
45106
187 4d90A02 - 54.3
18781
185 - - 60.9
45205
185 - - 69.5
7510
182 - - 66.6
45119
180 - - 75.4
24090
179 - - 61.0
44647
178 - - 38.7
1413
172 - - 86.2
45903
167 - - 80.8
7608
164 - - 69.3
1079
163 - - 75.6
44218
161 - - 64.3
44595
160 - - 56.5
44131
160 - - 84.2
44105
159 2y38A02 - 81.2
91
159 - - 82.8
45593
157 - - 80.6
28453
155 - - 82.0
46087
153 - - 91.1
21106
153 - - 83.3
45313
152 - - 90.0
45925
152 - - 89.7
28764
150 - - 6.5
24415
149 - - 60.2
22139
149 - - 80.8
45368
149 - - 88.3
45098
147 - - 52.6
25288
146 - - 63.7
30716
145 - - 52.2
45133
145 - - 82.4
43856
144 - - 71.9
44717
142 - - 50.7
45188
142 - - 76.3
24314
141 - - 71.6
16698
140 - - 66.9
46309
140 - - 66.2
45391
136 - - 66.1
22963
135 - - 78.1
46278
Ldl
134 3c9aC00 - 88.4
43952
129 - - 50.3
46595
129 - - 82.2
46244
Predicted
129 - - 81.1
364
128 - - 45.7
12805
127 - - 60.5
11602
127 - - 74.8
45182
127 3f1sB01 - 86.5
45321
126 - - 58.3
44507
126 - - 64.0
44520
126 - - 59.8
2902
125 - - 49.9
45490
125 - - 85.4
46130
125 - - 78.8
45032
124 1cqeA01 - 67.7
44675
123 - - 48.9
45240
123 - - 82.5
8146
121 - - 75.9
32132
120 - - 40.7
46523
120 - - 52.6
46301
119 - - 84.6
44125
119 1nziA02 - 74.6
45964
118 - - 86.1
44007
118 - - 61.9
45150
118 - - 69.6
46298
118 - - 62.6
44388
118 - - 72.7
45334
118 - - 73.4
44137
117 - - 52.2
30149
117 - - 50.5
10489
117 - - 74.7
44451
115 - - 74.4
5688
114 - - 36.0
44360
113 1u8cB04 - 41.2
44202
111 - - 54.2
5447
111 - - 66.0
13349
111 1moxC00 - 38.7
45648
110 - - 88.3
13741
110 3tbdA01 - 50.2
44397
109 - - 71.1
44584
108 - - 63.9
44350
107 - - 44.7
44472
107 - - 41.3
36099
105 - - 54.5
45289
105 - - 87.9
45072
105 - - 71.2
46221
104 - - 91.5
44282
103 - - 58.7
44316
102 - - 43.8
16845
101 - - 36.1
17413
101 - - 35.8
46255
101 - - 75.0
45036
100 - - 58.7
43771
100 - - 48.8
45714
100 - - 87.2
45646
100 - - 67.4
44012
100 - - 47.6
44071
99 - - 75.4
43873
98 - - 63.9
44512
97 - - 67.0
22071
97 - - 66.1
45220
97 - - 80.5
20281
96 - - 43.6
46387
94 - - 58.5
44036
94 - - 38.7
44086
94 - - 72.2
43910
94 - - 53.5
13926
94 - - 57.6
46057
93 - - 89.9
44780
93 - - 62.8
39759
93 - - 29.8
10521
92 - - 21.9
45529
92 1autL01 - 82.5
43944
91 - - 27.4
45116
91 2rhpA03 - 47.4
27672
91 - - 39.4
46303
91 - - 35.3
2350
90 - - 75.7
44600
Drosophila
90 - - 65.2
44107
90 - - 54.0
24400
90 - - 31.7
13747
89 - - 39.3
44214
89 - - 34.7
164
89 - - 24.7
18817
88 - - 59.3
43823
88 - - 71.8
45331
87 - - 20.2
45294
87 2bo2A03 - 72.6
44300
86 - - 66.4
44143
85 - - 55.4
30297
85 - - 25.0
43736
84 - - 64.8
43917
84 - - 35.9
2939
83 - - 81.2
44832
83 - - 41.1
45558
82 1dx5I03 - 83.8
44743
82 - - 66.5
9772
82 - - 17.3
4837
81 - - 52.1
37719
81 - - 22.5
46048
81 - - 62.1
1189
80 - - 63.5
45300
80 - - 69.4
44133
79 - - 51.6
20328
79 - - 38.1
44189
79 - - 20.2
44230
78 1k36A00 - 41.3
6081
78 - - 31.9
39169
78 - - 47.3
44106
78 - - 61.4
17233
78 - - 45.3
43728
77 2kl7A00 - 48.6
44164
77 - - 60.6
9458
77 - - 38.8
46401
76 - - 86.6
46569
76 1yukB02 - 68.3
26602
76 - - 37.8
9712
75 - - 43.8
44652
75 - - 45.0
24451
75 - - 37.2
44059
74 - - 38.7
20210
74 - - 51.1
46276
74 - - 85.1
45499
73 4bdwA00 - 79.8
44008
73 - - 45.5
18644
73 1cejA02 - 23.0
26614
73 - - 22.7
16061
72 - - 19.4
43812
72 - - 56.3
45393
72 - - 58.7
26592
71 - - 52.5
44575
71 - - 40.4
44614
71 - - 72.4
44869
71 - - 48.5
44576
71 - - 42.7
45359
70 - - 8.6
19150
69 - - 35.0
45982
69 - - 65.9
46140
68 2k2sB00 - 64.5
44458
68 - - 38.7
46296
67 - - 76.3
44467
67 - - 58.6
45059
66 - - 74.9
45447
66 - - 65.4
45094
65 - - 54.0
44395
65 - - 51.3
8614
65 - - 35.0
44724
64 - - 74.5
44438
64 - - 45.0
46053
64 - - 81.6
43721
63 - - 54.1
45361
63 - - 84.4
44130
63 1kloA03 - 61.8
45904
62 - - 77.0
7407
62 - - 50.9
45097
62 2w86A03 - 38.5
45225
62 - - 62.6
494
62 - - 42.0
44553
62 - - 34.5
43889
61 - - 44.5
44136
61 - - 54.4
37084
61 - - 22.6
45367
60 3fbyA01 - 73.4
9584
60 - - 35.0
44849
60 - - 41.7
29367
59 - - 41.2
44295
57 - - 20.3
44455
56 - - 43.6
45063
56 - - 80.6
7852
56 - - 41.8
31767
Drosophila
55 - - 34.4
36154
55 - - 46.6
22074
55 - - 20.6
24413
55 - - 57.1
37139
55 - - 48.5
19278
55 - - 40.4
41118
54 - - 39.9
45166
54 - - 58.7
33508
54 - - 50.6
5808
53 - - 60.7
45655
53 - - 84.2
1434
53 - - 41.7
45178
53 - - 43.9
21882
52 - - 6.5
43829
52 - - 62.9
7482
52 - - 37.5
43940
51 - - 30.6
44277
51 - - 51.3
24553
51 - - 18.7
44414
50 - - 38.5
21096
50 - - 39.7
37266
49 - - 22.0
44091
49 - - 52.5
44368
49 - - 61.2
43935
48 - - 34.9
44541
48 - - 70.0
44460
47 - - 35.3
46080
47 - - 47.8
1833
47 - - 19.2
44021
46 - - 41.9
45073
45 - - 44.4
46227
44 - - 83.6
6986
44 - - 31.0
44969
44 - - 47.4
45423
44 - - 67.4
5754
43 - - 2.2
44379
43 - - 57.9
44564
43 - - 71.1
32154
43 - - 5.3
43918
43 - - 42.7
46385
Ldl
42 - - 69.8
43844
42 - - 18.6
45086
41 - - 48.3
39425
41 - - 39.3
43966
40 - - 43.9
14145
40 - - 22.5
12365
40 - - 39.7
44325
39 - - 38.8
1754
39 - - 65.3
947
39 - - 88.2
655
39 1z6cA00 - 53.9
25889
39 - - 56.7
10158
38 - - 31.1
3711
38 - - 28.8
44303
37 - - 42.7
44128
37 - - 59.3
17249
36 - - 0.0
34855
35 - - 24.4
46557
35 - - 62.2
45105
35 - - 72.0
44577
35 - - 49.0
44103
34 - - 43.8
1414
34 - - 21.0
34854
34 - - 40.4
44805
34 - - 43.1
44045
34 - - 28.8
45966
33 - - 56.4
9604
33 - - 21.3
32488
33 - - 45.0
39716
33 - - 23.0
5390
33 2bo2A01 - 30.5
44038
Predicted
32 - - 54.9
3708
31 - - 13.4
45138
31 - - 52.6
44694
30 - - 70.9
43880
29 - - 35.5
43916
29 - - 50.6
41832
29 - - 85.5
45230
28 - - 39.9
43742
28 - - 87.0
45676
28 - - 80.2
45147
27 - - 61.7
43895
27 - - 38.7
22213
25 - - 22.4
28708
25 - - 49.5
45309
25 - - 68.4
43765
25 - - 36.1
15041
25 - - 24.1
26630
25 - - 0.0
43725
25 - - 34.0
27327
25 - - 38.0
18485
25 - - 17.8
18451
25 - - 19.3
44679
24 - - 46.4
44353
23 - - 6.9
45401
22 - - 80.0
44075
22 - - 58.6
44565
22 - - 53.4
9592
22 - - 34.0
7158
21 - - 11.7
38262
21 - - 0.0
18625
20 - - 34.9
45238
19 - - 50.6
44616
Drosophila
19 - - 53.7
8148
19 - - 5.0
43737
19 - - 20.0
9042
19 - - 17.0
9593
19 - - 0.0
9594
19 - - 2.5
10545
19 - - 12.2
32322
19 - - 25.9
38644
18 - - 45.8
46310
18 - - 51.3
22121
18 - - 17.0
9619
18 2bo2A02 - 17.7
45107
17 - - 33.6
8719
17 - - 26.4
17257
17 - - 31.3
4843
17 - - 35.6
36305
17 - - 12.6
46263
16 - - 62.9
12971
16 - - 19.0
17264
16 - - 6.5
17258
16 - - 16.6
44469
15 - - 36.1
38027
15 - - 19.1
9627
15 - - 14.3
45990
15 - - 27.6
46406
15 1ccvA00 - 89.9
7589
15 - - 36.9
45886
15 - - 65.0
44946
15 - - 33.5
38478
15 - - 14.8
45715
15 - - 56.1
43954
15 1apqA00 - 27.1
45563
15 - - 37.5
46129
15 - - 57.4
41822
14 - - 7.3
20219
14 - - 33.3
15038
14 - - 30.3
13737
14 - - 15.2
2946
14 - - 18.2
3853
14 - - 9.7
7253
13 - - 13.1
13143
13 - - 17.3
17276
13 - - 16.2
14299
13 - - 12.0
32619
13 - - 25.9
10483
13 - - 7.6
6478
13 - - 36.7
15114
12 - - 22.0
45177
12 - - 55.6
17277
12 - - 17.0
44027
12 - - 41.5
7675
12 - - 24.3
22804
12 - - 17.6
11604
12 - - 7.8
12594
12 - - 22.2
27068
12 - - 6.7
45286
12 - - 18.4
45747
12 - - 55.1
7591
12 - - 9.8
8717
11 - - 12.4
44484
11 - - 13.3
43831
11 - - 30.6
12067
11 - - 8.0
16063
11 5cisA02 - 11.4
11608
11 - - 28.7
44342
10 - - 53.9
43719
10 - - 17.0
44585
10 - - 51.2
15060
10 - - 19.8
13771
10 - - 13.9
8400
10 - - 17.9
7611
10 - - 8.7
3265
10 - - 25.3
11574
9 - - 5.5
8710
9 - - 24.6
9623
9 - - 5.1
31155
9 - - 22.0
17251
9 - - 14.6
43941
9 1eaiC00 - 32.7
10595
9 - - 38.8
22134
9 - - 0.0
20324
8 - - 16.5
2940
8 - - 4.5
32116
8 - - 0.0
30029
8 - - 0.0
12593
8 - - 11.5
12590
8 - - 17.8
7606
8 - - 14.0
10547
8 - - 20.1
22072
8 - - 8.7
22238
8 - - 10.0
14394
8 - - 4.5
12738
8 - - 10.9
45960
8 - - 0.0
46137
7 - - 63.6
34850
7 - - 10.9
12392
7 - - 0.0
4024
7 - - 22.1
45568
7 - - 0.0
45504
7 - - 43.4
22518
7 - - 0.0
10533
7 - - 9.8
6482
7 - - 6.8
10551
7 - - 2.6
1318
7 - - 17.8
7007
7 - - 9.0
36067
7 - - 3.3
5081
7 1ataA00 - 10.7
36066
7 - - 20.7
45411
7 - - 37.8
5080
7 - - 10.5
38489
7 - - 6.5
37575
7 - - 14.2
29559
6 - - 11.4
9823
6 - - 17.0
8543
6 - - 11.3
4149
6 - - 23.3
7356
6 - - 16.0
44274
6 - - 36.4
17242
6 - - 3.1
20500
6 - - 0.0
44503
6 - - 31.3
6493
6 - - 0.0
45907
6 - - 49.0
8903
6 - - 2.5
24019
6 - - 10.1
18746
6 - - 5.5
44519
DNER
6 - - 2.6
45741
6 - - 64.2
9428
6 - - 14.9
8905
5 - - 14.9
28754
5 - - 0.0
43761
5 - - 1.1
20358
5 - - 27.7
45977
Drosophila
5 - - 47.4
42897
5 - - 18.5
4187
5 - - 2.9
17240
5 - - 0.0
43883
5 - - 3.0
11814
5 - - 2.5
29214
5 - - 11.9
38450
5 - - 14.8
45323
5 - - 16.1
45112
5 - - 44.4
17436
5 - - 15.3
19352
5 - - 26.4
10604
5 - - 5.2
6150
5 - - 19.1
24468
5 - - 18.2
26229
5 - - 5.9
15503
5 - - 18.6
2355
5 - - 0.0
10932
5 - - 11.9
43874
5 - - 20.1
31889
5 - - 8.5
17259
5 - - 48.7
13765
5 - - 5.2
33518
5 - - 9.2
12597
5 - - 19.0
37261
5 - - 0.0
18069
5 - - 28.4
18998
4 - - 17.4
846
4 - - 0.0
5508
4 - - 2.4
1025
4 - - 4.4
2690
4 - - 7.2
28725
4 - - 11.3
5004
4 - - 4.0
41842
4 - - 0.0
11933
4 - - 10.6
30677
4 - - 10.5
45120
4 - - 14.7
38584
4 - - 3.9
7298
4 - - 7.1
13957
4 - - 5.9
12595
4 - - 2.1
24158
4 - - 10.6
44994
4 - - 53.3
14935
4 - - 27.0
8759
4 - - 3.4
18660
4 - - 0.0
22061
4 - - 6.9
24608
4 - - 6.0
13770
4 - - 0.0
22098
3 - - 7.6
7141
3 - - 0.0
45044
3 - - 0.0
4836
3 - - 1.8
30621
3 - - 5.3
44922
3 - - 23.9
4144
3 - - 1.1
6500
3 - - 8.4
22087
3 - - 11.6
6763
3 - - 0.0
43850
3 - - 15.2
1701
3 - - 0.0
44491
3 - - 35.2
28864
3 - - 2.8
41262
3 - - 4.0
9357
3 - - 7.3
18663
3 - - 22.0
44951
3 - - 3.2
25166
3 - - 0.0
37252
3 - - 9.0
44305
3 - - 5.0
31190
3 - - 10.9
44903
3 - - 0.0
44593
3 - - 18.9
15968
3 - -
19329
3 - - 0.0
22099
3 - - 16.9
30612
3 - - 7.5
16785
3 - - 5.5
30583
3 - - 0.0
34869
3 - - 14.4
17237
2 - - 0.0
6609
2 - - 0.0
6657
2 - - 3.8
30743
2 - - 0.0
16332
2 - - 15.1
38452
2 - - 3.9
10556
2 - - 0.0
4474
2 - - 24.6
40424
2 - - 0.0
6092
2 - - 0.0
16543
Predicted
2 - - 0.0
36097
2 - - 0.0
43930
2 - - 21.1
17667
2 - - 0.0
24470
2 - - 7.4
30597
2 - - 9.0
12600
2 - - 0.0
14129
2 - - 0.0
5832
2 - - 0.0
11868
2 - - 11.6
25325
Drosophila
2 - - 24.6
12571
2 - - 4.6
45144
2 - - 0.0
30609
2 - - 10.6
44035
2 - - 17.7
17279
2 - - 0.0
44983
2 - - 19.8
31347
2 - - 6.3
18664
2 - - 0.0
26621
2 - - 14.7
12553
2 - - 0.0
7454
2 - - 0.0
33472
2 - - 0.0
15057
2 - - 10.5
29716
2 - - 0.0
44609
2 - - 29.5
11177
2 - - 5.3
20361
2 - - 10.7
23148
2 - - 3.1
36277
2 - - 10.9
3492
2 - - 2.2
10536
2 - - 0.0
4542
2 - -
38475
2 - - 0.0
17280
2 - - 0.0
34880
2 - - 0.0
43797
2 - -
43819
2 - - 19.5
45370
2 - - 10.7
30623
2 - - 17.1
30369
2 - - 0.0
14131
2 - - 0.0
45895
2 - - 0.0
17488
2 - - 10.0
14710
2 - - 0.0
34871
2 - - 0.0
11635
2 - - 0.0
25195
1 - - 0.0
30608
1 - - 0.0
15254
1 - - 0.0
3525
1 - - 0.0
14736
1 - - 0.0
32424
1 - - 0.0
44599
1 3fcsD04 - 0.0
45316
1 - -
42071
1 - - 0.0
46413
1 - - 0.0
38588
1 - - 0.0
8385
1 - - 0.0
11651
1 - - 0.0
11428
1 - - 0.0
44836
1 - -
37222
1 - - 0.0
2168
LTBP4
1 - - 0.0
14054
Predicted
1 - - 0.0
34656
1 - - 0.0
46181
1 - - 0.0
32983
1 - - 0.0
40619
1 - - 0.0
44175
1 - -
45161
1 - -
10862
1 - - 0.0
6084
1 - - 0.0
45187
1 - - 0.0
46086
1 - - 0.0
1201
1 - - 0.0
24402
1 - - 0.0
43158
1 - - 0.0
35820
1 - - 0.0
17234
1 - - 0.0
6920
1 - - 0.0
30796
1 - - 0.0
15033
1 - - 0.0
44407
1 - - 0.0
16062
1 - -
24439
1 - - 0.0
13744
1 - - 0.0
5774
1 - - 0.0
26278
1 - -
46121
1 - - 0.0
34884
1 - - 0.0
45001
1 - -
37835
1 - - 0.0
6937
1 - - 0.0
29293
1 - - 0.0
16400
1 - - 0.0
19886
1 - -
10535
1 - - 0.0
45322
1 - - 0.0
29840
1 - -
12658
1 - - 0.0
26620
1 - - 0.0
38472
1 - - 0.0
44051
1 - -
36676
1 - - 0.0
13805
1 - - 0.0
34921
1 - - 0.0
46322
1 - - 0.0
157
1 1lmjA00 - 0.0
8714
1 - - 0.0
5397
1 - - 0.0
18941
1 - - 0.0
37403
1 - - 0.0
13745
1 - - 0.0
35361
1 - -
7036
1 - - 0.0
8705
1 - - 0.0
39539
1 - - 0.0
32866
1 - - 0.0
44298
1 - - 0.0
16882
1 - - 0.0
9360
1 - - 0.0
45279
1 - - 0.0
16109
1 - - 0.0
27785
1 - - 0.0
5138
1 - - 0.0
14217
1 - - 0.0
20290
1 - - 0.0
45259
1 - - 0.0