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CATH Superfamily 2.10.220.10

Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Receptor protein-tyrosine kinase
816
3D
 4uv7A02 - 93.0
2
Receptor protein-tyrosine kinase
427
3D
 4krpA03 - 79.9
3
R-spondin 3
230
3D
 4li2B00 - 75.8
4
Receptor protein-tyrosine kinase
198
3D
 3u9uF04 - 43.6
5
Tyrosine-protein kinase receptor
182
3D
 5j3hE02 - 67.2
6
Receptor protein-tyrosine kinase
153
3D
 4hrnD00 - 64.3
12
R-spondin 4
150
3D
 4ufrD00 - 78.9
8
Receptor protein-tyrosine kinase
149
3D
 4uv7A04 - 60.6
7
Tyrosine-protein kinase receptor
142
3D
 1igrA02 - 75.9
10
Receptor protein-tyrosine kinase
142
3D
 3wsqA02 - 74.3
9
Receptor protein-tyrosine kinase
137
3D
 3n85A04 - 42.4
11
Proprotein convertase subtilisin/kexin type 5
131 - - 74.2
13
Receptor protein-tyrosine kinase
93 - - 77.2
14
Tyrosine-protein kinase receptor
89 - - 77.5
15
proprotein convertase subtilisin/kexin type 6
83 - - 66.0
16
Receptor tyrosine-protein kinase erbB-3
70
3D
 4p59A04 - 53.2
17
Proprotein convertase subtilisin/kexin type 6
53 - - 51.7
18
Proprotein convertase subtilisin/kexin type 5
50 - - 73.2
19
Proprotein convertase subtilisin/kexin type 6
46 - - 57.6
20
Furin-like protease 2
44 - - 57.4
21
proprotein convertase subtilisin/kexin type 6
42 - - 70.2
22
proprotein convertase subtilisin/kexin type 5 isoform X2
41 - - 72.2
23
Furin, paired basic amino acid cleaving enzyme
41 - - 85.9
24
Receptor protein-tyrosine kinase
32 - - 91.8
25
Proprotein convertase subtilisin/kexin type 5
30 - - 34.8
26
Fraser extracellular matrix complex subunit 1
29 - - 88.8
29
Proprotein convertase subtilisin/kexin type 5
28 - - 45.3
27
Tyrosine-protein kinase receptor
28 - - 71.2
28
Fraser extracellular matrix complex subunit 1
28 - - 46.9
30
Proprotein convertase subtilisin/kexin type 5
28 - - 54.6
31
Furin 2, isoform A
27 - - 23.7
32
Proprotein convertase subtilisin/kexin type 5
26 - - 71.7
33
Proprotein convertase subtilisin/kexin type 5
25 - - 73.6
34
Proprotein convertase subtilisin/kexin type 5
24 - - 67.4
35
Proprotein convertase subtilisin/kexin type 5
23 - - 71.5
36
Receptor protein-tyrosine kinase
23 - - 16.8
37
Proprotein convertase subtilisin/kexin type 5
21 - - 81.3
38
Fraser extracellular matrix complex subunit 1
21 - - 53.1
39
Extracellular matrix protein FRAS1
19 - - 26.9
40
Proprotein convertase subtilisin/kexin type 5
19 - - 82.0
41
Receptor protein-tyrosine kinase
18 - - 17.0
43
Proprotein convertase subtilisin/kexin type 5b
17 - - 81.5
42
Proprotein convertase subtilisin/kexin type 5
17 - - 65.9
44
Proprotein convertase subtilisin/kexin type 5
16 - - 58.5
45
Proprotein convertase subtilisin/kexin type 4
15 - - 69.4
46
Proprotein convertase subtilisin/kexin type 5b
14 - - 62.2
48
Proprotein convertase subtilisin/kexin type 6
12 - - 60.6
47
Proprotein convertase subtilisin/kexin type 6
12 - - 45.1
49
Proprotein convertase subtilisin/kexin type 5
11 - - 77.8
50
Proprotein convertase subtilisin/kexin type 5
11 - - 88.5
51
Proprotein convertase subtilisin/kexin type 5
10 - - 67.2
52
proprotein convertase subtilisin/kexin type 6 isoform X1
10 - - 71.5
53
Proprotein convertase subtilisin/kexin type 5
10 - - 77.9
55
Furin-like protease 2
9 - - 78.2
57
Proprotein convertase subtilisin/kexin type 5
9 - - 83.5
56
Fraser extracellular matrix complex subunit 1
9 - - 7.1
54
Fraser extracellular matrix complex subunit 1
9 - - 31.3
58
Fraser extracellular matrix complex subunit 1
8 - - 15.0
60
Fraser extracellular matrix complex subunit 1
8 - - 7.6
59
Fraser extracellular matrix complex subunit 1
8 - - 6.9
61
Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
7 - - 40.4
63
Furin 2, isoform D
7 - - 5.9
62
Extracellular matrix protein FRAS1
7 - - 72.1
68
Receptor protein-tyrosine kinase
6 - - 23.0
64
Proprotein convertase subtilisin/kexin type 5
6 - - 17.8
69
Fraser extracellular matrix complex subunit 1
6 - - 18.3
65
Receptor protein-tyrosine kinase
6 - - 40.2
66
Receptor protein-tyrosine kinase
6 - - 28.2
67
Proprotein convertase subtilisin/kexin type 5
6 - - 43.2
71
Gal/GalNAc lectin Igl2, putative
5 - - 0.0
78
Receptor protein-tyrosine kinase
5 - - 39.0
74
High cysteine membrane protein TMK-like
5 - - 11.4
80
Fraser extracellular matrix complex subunit 1
5 - - 5.6
81
Proprotein convertase subtilisin/kexin type 5
5 - - 55.8
75
Fraser extracellular matrix complex subunit 1
5 - - 20.1
76
Proprotein convertase subtilisin/kexin type 5
5 - - 47.4
77
High cysteine membrane protein TMK-like
5 - - 20.2
79
Furin-like protease 2
5 - - 49.5
72
CXXC-rich protein
5 - - 2.6
73
CXXC-rich, putative
5 - - 0.0
70
Erb-b2 receptor tyrosine kinase 3b
5 - - 0.0
85
Proprotein convertase subtilisin/kexin type 6
4 - - 52.8
89
Furin 2
4 - - 11.6
91
Proprotein convertase subtilisin/kexin type 5
4 - - 76.0
82
Proprotein convertase subtilisin/kexin type 5a
4 - - 30.9
90
Fraser extracellular matrix complex subunit 1
4 - - 64.7
86
R-spondin-3
4 - - 73.1
87
High cysteine membrane protein TMK-like
4 - - 7.4
84
Uncharacterized protein
4 - - 31.3
83
Proprotein convertase subtilisin/kexin type 5a
4 - - 32.4
88
Insulin-like receptor
4 - - 9.4
101
Fraser extracellular matrix complex subunit 1
3 - - 4.0
96
Furin-like protease 2
3 - - 46.6
92
Epidermal growth factor receptor a
erythroblastic leukemia viral (v-erb-b
3 - - 13.7
105
Tyrosine-protein kinase receptor
3 - - 0.0
94
Proprotein convertase subtilisin/kexin type 5
3 - - 34.6
99
Receptor protein-tyrosine kinase
3 - - 0.0
95
Proprotein convertase subtilisin/kexin type 6
3 - - 40.1
106
Proprotein convertase subtilisin/kexin type 5a
3 - - 5.8
98
Tyrosine-protein kinase receptor
3 - - 18.1
102
R-spondin 2
3 - - 6.1
100
Receptor protein-tyrosine kinase
3 - - 0.0
93
Proprotein convertase subtilisin/kexin type 5
3 - - 41.7
104
Receptor protein-tyrosine kinase
3 - - 1.0
103
Tyrosine-protein kinase receptor
3 - - 1.6
97
Receptor protein-tyrosine kinase
3 - - 47.9
127
Tyrosine-protein kinase receptor
2 - - 0.0
153
Receptor protein-tyrosine kinase
2 - - 1.1
136
Proprotein convertase subtilisin/kexin type 5
2 - - 3.5
116
Proprotein convertase subtilisin/kexin type 5
2 - - 3.6
137
Proprotein convertase subtilisin/kexin type 5a
2 - - 5.7
112
Furin-like protease 2
2 - - 45.5
108
Fraser extracellular matrix complex subunit 1
2 - - 13.8
142
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
128
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
155
Receptor protein-tyrosine kinase
2 - - 36.4
154
Proprotein convertase subtilisin/kexin type 5
2 - - 44.8
132
Tyrosine-protein kinase receptor
2 - - 9.8
147
Putative furin-like protease 2
2 - - 13.4
117
Proprotein convertase subtilisin/kexin type
2 - - 10.3
149
Proprotein convertase subtilisin/kexin type 5
2 - - 8.3
111
Furin2, putative
2 - - 43.0
139
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
129
Uncharacterized protein
2 - - 4.2
135
Uncharacterized protein
2 - - 4.0
145
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
124
Furin-like protease 2
2 - - 6.8
113
Uncharacterized protein
2 - - 0.0
152
Proprotein convertase subtilisin/kexin type 5
2 - - 1.1
120
Proprotein convertase subtilisin/kexin type 5
2 - - 3.3
109
Proprotein convertase subtilisin/kexin type 5
2 - - 11.8
131
Uncharacterized protein
2 - - 3.6
148
Proprotein convertase subtilisin/kexin type 5
2 - - 8.6
121
Receptor protein-tyrosine kinase
2 - - 3.9
141
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
146
Proprotein convertase subtilisin/kexin type 5
2 - - 2.9
119
Proprotein convertase subtilisin/kexin type 5
2 - - 2.6
107
Uncharacterized protein
2 - - 0.0
144
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
151
Proprotein convertase subtilisin/kexin type 5
2 - - 1.1
138
Fraser extracellular matrix complex subunit 1
2 - - 0.0
110
High cysteine membrane protein TMK-like
2 - - 13.4
130
Proprotein convertase subtilisin/kexin type 5
2 - - 3.1
140
Proprotein convertase subtilisin/kexin type 5
2 - - 4.8
115
Proprotein convertase subtilisin/kexin type 5
2 - - 6.8
122
Erb-b2 receptor tyrosine kinase 3a
2 - - 0.0
125
R-spondin 1
2 - - 0.0
118
Putative furin-like protease 2
2 - - 5.9
126
Endoprotease bli-4
2 - - 1.7
150
R-spondin-3
2 - - 0.0
114
Proprotein convertase subtilisin/kexin type 5
2 - - 1.2
143
Proprotein convertase subtilisin/kexin type 5
2 - - 0.0
133
receptor tyrosine-protein kinase erbB-4-like
2 - - 0.0
123
Fibronectin domain-containing protein
2 - - 0.0
134
Proprotein convertase subtilisin/kexin type 5
2 - - 3.4
180
Uncharacterized protein
1 - - 0.0
191
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
187
Predicted protein
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
170
Uncharacterized protein
1 - - 0.0
207
Predicted protein
1 - - 0.0
175
Proprotein convertase subtilisin/kexin type 4
1 - - 0.0
198
Uncharacterized protein
1 - - 0.0
202
Predicted protein
1 - - 0.0
184
Uncharacterized protein
1 - - 0.0
181
Uncharacterized protein
1 - - 0.0
222
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
217
Extracellular matrix protein FRAS1
1 - - 0.0
158
Uncharacterized protein
1 - - 0.0
165
Receptor protein-tyrosine kinase
1 - - 0.0
209
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
210
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
168
Uncharacterized protein
1 - - 0.0
178
Extracellular matrix protein FRAS1
1 - - 0.0
213
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
200
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
161
Fraser extracellular matrix complex subunit 1
1 - - 0.0
224
Predicted protein
1 - - 0.0
192
Uncharacterized protein
1 - - 0.0
199
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
195
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
174
Uncharacterized protein
1 - - 0.0
188
Uncharacterized protein
1 - - 0.0
183
Receptor protein-tyrosine kinase
1 - - 0.0
157
High cysteine membrane protein Group 5
1 - - 0.0
203
Receptor protein-tyrosine kinase
1 - - 0.0
204
Uncharacterized protein
1 - - 0.0
179
AGAP002915-PA
1 - - 0.0
164
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
211
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
218
Uncharacterized protein
1 - - 0.0
160
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
193
Predicted protein
1 - - 0.0
189
Uncharacterized protein
1 - - 0.0
221
Predicted protein
1 - - 0.0
177
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
205
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
167
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
163
CXC-rich protein
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
186
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
173
Uncharacterized protein
1 - - 0.0
156
Uncharacterized protein
1 - - 0.0
219
Furin2, putative
1 - - 0.0
196
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
206
Uncharacterized protein
1 - - 0.0
194
Uncharacterized protein
1 - - 0.0
220
Proprotein convertase subtilisin/kexin type 4, furin, putative
1 - - 0.0
171
Uncharacterized protein
1 - - 0.0
197
Erb-b2 receptor tyrosine kinase 3a
1 - - 0.0
176
Uncharacterized protein
1 - - 0.0
215
Erb-b2 receptor tyrosine kinase 3a
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
159
Uncharacterized protein
1 - - 0.0
162
Uncharacterized protein
1 - - 0.0
201
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
169
Tyrosine-protein kinase receptor
1 - - 0.0
190
Uncharacterized protein
1 - - 0.0
172
Uncharacterized protein
1 - - 0.0
223
Proprotein convertase subtilisin/kexin type 5a
1 - - 0.0
216
Proprotein convertase subtilisin/kexin type 5
1 - - 0.0
166
Uncharacterized protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0