The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Alkyl sulfatase, dimerisation domain

The SDS hydrolase SdsA1 secreted by Pseudomonas aeruginosa, which enables the bacterium to use primary sulfates such as SDS as a sole carbon or sulfur source, is one of the best characterised alkyl sulfatases. The crystal structure of SdsA1 revealed three distinct domains: an N-terminal catalytic domain with a binuclear Zn2+ cluster which is a distinct member of the metallo-beta-lactamase fold family, a central dimerization domain that ensures resistance to high concentrations of SDS, and a C-terminal domain provides a hydrophobic groove, presumably to recruit long aliphatic substrates PMID:16684886,PMID:23061549.

Structural domains comprising this superfamily share the structure of the alpha helical dimerisation domain of alkyl sulfatases.

GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
2065 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 29
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 1
Unique PDBs: 12
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 5
Unique GO: 5
Unique Species: 2065