The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
70133
4650
3D
1wa5C00 - 81.4
69548
4511
3D
3h3dX00 - 78.1
70285
4094
3D
1upkA01 - 79.3
69381
4083
3D
2jkrB00 - 79.8
69176
3962
EC
3D
2iaeB01 - 83.6
69631
3691
EC
3D
2jdqA00 - 82.5
69281
3673
EC
3D
2jkrA01 - 81.8
69033
3098
EC
3D
2fv2A00 - 81.0
70227
2829
3D
1oyzA00 - 91.2
70255
2819
EC
- - 78.0
69180
1971
EC
3D
3w3uA01 - 79.0
69058
1890
EC
3D
1qgkA00 - 83.3
68662
1591
EC
3D
1b3uA00 - 83.6
69086
1579
3D
4k92A00 - 96.7
69430
1503
3D
1qbkB00 - 76.9
68909
Eurofung
1471 - - 80.5
69909
1469
EC
3D
1i7wA00 - 89.3
68699
1448
EC
3D
1u6gC00 - 82.1
68666
1442 - - 94.7
69024
1410
3D
3gb8A01 - 82.5
69540
1385
EC
- - 92.3
69089
1383 - - 78.6
68791
1298 - - 92.7
69791
DOHH
1246
EC
- - 77.3
69002
1146
EC
3D
1w9cA00 - 84.8
69200
1128
3D
3ibvA00 - 85.6
69570
EF-3
999
EC
3D
2iw3A01 - 95.2
69739
933 - - 89.4
10704
Importin
902
3D
4uaeA00 - 90.2
69236
835
EC
- - 80.2
69095
812
EC
- - 87.7
69019
776
EC
- - 80.0
69161
764
3D
3dadA00 - 89.7
61812
760
EC
- - 49.9
4745
724
3D
1w63A00 - 78.6
69503
720 - - 73.8
69983
636
EC
- - 86.0
69164
Cadherin-associated protein
626
3D
3l6yA01 - 86.7
68643
617 - - 77.1
68920
609 - - 91.8
68883
600 - - 68.9
69113
590 - - 80.8
69526
583
EC
- - 81.1
69529
569 - - 74.8
69088
521
EC
- - 91.0
69624
468 - - 93.7
68921
451
EC
- - 92.7
68861
427
3D
3au3A00 - 86.0
68912
425
EC
- - 74.5
69017
419 - - 93.9
68951
410
3D
4c0qB00 - 87.0
68817
406 - - 82.5
69995
385 - - 79.5
34282
381 - - 78.6
69148
378 - - 89.1
68516
377 - - 65.5
68871
Drosophila
348 - - 82.5
68789
344 - - 91.3
69640
316
EC
- - 98.9
69793
308 - - 93.6
69978
304 - - 84.0
69146
298 - - 94.7
15931
291 - - 84.9
69008
289 - - 80.7
69893
279
3D
2x1gF00 - 77.7
69028
279 - - 89.4
69020
271 - - 90.3
69031
261
EC
- - 82.1
69308
260 - - 81.8
68741
257
EC
- - 82.0
69136
248
EC
- - 90.8
69525
244 - - 71.1
69411
230
3D
3tt9A00 - 89.9
68877
219 - - 89.9
69142
213 - - 74.5
69144
Cadherin-associated protein
212
3D
3l6xA01 - 80.8
64119
204 - - 53.7
17672
194
EC
- - 82.8
68747
194 - - 96.8
69246
190
EC
- - 89.2
68805
185 - - 76.0
69478
179 - - 69.3
69649
174 - - 75.3
69158
168 - - 88.8
69694
168 - - 74.5
68772
164
3D
2w3cA01 - 79.4
22023
163 - - 89.4
4994
163 - - 87.9
70077
162 - - 74.3
68965
160
EC
- - 73.7
69317
156 - - 89.0
68822
154 - - 82.0
70057
151
EC
- - 95.0
69043
151 - - 74.7
69730
146
EC
- - 93.7
68524
145 - - 71.6
47130
140 - - 71.6
49035
140
EC
- - 73.5
69891
138
3D
4i2wA03 - 88.8
68827
138 - - 86.7
44093
136 - - 68.7
69044
133 - - 82.4
68715
133 - - 85.2
68734
130
EC
- - 90.6
69319
Eurofung
130 - - 94.6
69165
130 - - 93.1
69051
122 - - 90.9
69452
117 - - 92.9
68313
115 - - 48.2
32683
113 - - 56.5
69066
110 - - 32.1
69479
110 - - 68.3
39498
Drosophila
108
3D
1z2cB02 - 45.3
56786
108 - - 72.6
68815
107
EC
- - 67.5
69021
104 - - 54.6
68974
102 - - 78.1
69392
101
EC
- - 76.0
35069
97 - - 52.0
69099
93 - - 63.3
69520
90 - - 57.2
70084
90
EC
- - 94.3
69056
90 - - 84.2
69412
87
EC
- - 36.8
68751
86 - - 41.9
62684
85 - - 52.1
54166
84 - - 63.3
53724
82 - - 80.0
69915
81 - - 65.9
68560
81 - - 54.2
4378
79 - - 55.3
69104
75 - - 58.2
44402
74 - - 55.8
69004
74 - - 92.7
69878
72
EC
- - 93.4
69115
72 - - 60.2
68580
70 - - 60.3
69082
69 - - 61.2
49034
68 - - 48.5
70222
65 - - 65.2
22770
63
3D
1ho8A01 - 23.3
49895
59 - - 34.5
68983
59
EC
- - 59.3
69509
58 - - 64.7
68919
57 - - 72.3
70581
56 - - 72.8
68682
54 - - 69.9
69606
53 - - 75.1
35948
52
3D
3vwaA03 - 20.3
70371
48 - - 61.8
68906
48 - - 56.9
3373
48 - - 19.5
28926
48 - - 52.1
39968
47 - - 39.9
69527
44 - - 68.1
70051
44
EC
- - 67.3
22417
44
EC
- - 67.3
33712
44
3D
1xqrA00 - 34.3
39971
43 - - 40.6
62080
42 - - 49.0
68915
42 - - 48.2
69250
40 - - 73.3
17165
39 - - 50.0
69968
38 - - 93.7
68522
38 - - 48.1
48745
36 - - 43.9
69229
33 - - 61.2
69435
32 - - 77.8
69413
31
EC
- - 38.5
1745
31 - - 0.7
69112
31
EC
- - 67.2
70621
28 - - 87.7
63475
28
EC
- - 40.7
54837
28 - - 79.3
50231
27 - - 23.0
45288
27 - - 50.8
69715
27 - - 92.2
69483
27
EC
- - 90.3
68910
25 - - 22.8
69027
24 - - 37.6
68465
24 - - 48.0
69126
23 - - 57.6
69517
23 - - 40.5
69845
23 - - 69.5
69052
22 - - 11.0
35925
22 - - 2.1
69563
22 - - 78.9
38332
21 - - 18.3
69156
21 - - 77.5
69259
20 - - 47.1
70439
19 - - 16.9
60333
19
EC
- - 35.7
15590
19 - - 35.5
68569
18 - - 38.1
69963
18
EC
- - 67.3
69169
17 - - 75.6
54791
17 - - 42.1
69682
15 - - 27.1
68777
15 - - 42.0
37866
14 - - 6.5
1760
14 - - 15.4
20466
14 - - 37.0
45994
14 - - 20.8
9206
14 - - 38.4
44963
13 - - 13.8
69475
13
EC
- - 19.9
16863
13 - - 31.5
56764
13 - - 38.0
68518
13 - - 59.5
68940
12 - - 29.9
70243
12
EC
- - 30.4
69224
12
EC
- - 42.0
54330
12
EC
- - 2.7
10649
12 - - 2.2
68770
12 - - 39.2
35890
11 - - 0.0
45562
11 - - 38.4
69258
11 - - 71.1
69307
11 - - 66.1
65426
11 - - 15.1
64028
11
EC
- - 23.3
1187
11 - - 1.8
69061
11 - - 43.1
69578
11
EC
- - 42.9
41368
10 - - 16.0
45784
10 - - 36.3
69438
10 - - 22.1
53483
10
EC
- - 26.4
34594
9
EC
- - 33.3
68696
9 - - 45.3
68948
9 - - 18.7
29588
9 - - 23.2
56931
9
EC
- - 19.0
14099
9 - - 8.7
70277
9 - - 27.3
69032
9 - - 50.5
68336
8 - - 16.3
68766
8 - - 26.2
44243
8 - - 0.5
68322
8 - - 33.0
53149
8
EC
- - 21.5
27509
7 - - 23.3
16514
7 - - 47.3
70214
7 - - 50.8
16941
7 - - 0.0
69671
7 - - 22.0
57607
7 - - 17.1
55315
7 - - 8.4
53858
6
EC
- - 29.0
69151
6 - - 48.6
58466
6 - - 26.2
70135
6 - - 31.8
51156
6 - - 17.1
47160
6 - - 19.0
46167
6
EC
- - 31.3
29447
6 - - 0.0
68917
5
EC
- - 20.5
69789
5 - - 47.7
19713
5
EC
- - 0.0
52356
5 - - 25.2
70484
5 - - 0.0
68724
5 - - 24.0
63349
4 - - 0.0
59515
4 - - 9.9
70242
4 - - 24.0
69676
4 - - 31.2
36085
4 - - 7.8
26298
4 - - 10.1
46497
4 - - 0.0
56395
4
EC
- - 19.7
60182
4 - - 0.0
69848
4 - - 29.9
28910
4 - - 10.2
69868
4 - - 25.6
69352
4 - - 14.4
68482
3 - - 12.5
47159
3 - - 2.8
69039
3 - - 18.0
47574
3 - - 7.5
60009
3 - - 9.4
43573
3 - - 9.4
60879
3 - - 23.8
61809
3
EC
- - 17.3
69204
3 - - 13.3
69599
3 - - 44.4
70207
3 - - 33.7
18980
3 - - 28.8
70120
3 - - 46.8
39606
3
EC
- - 7.8
20150
3 - - 9.4
69232
3 - - 36.1
32614
3 - - 5.6
70021
3
EC
- - 2.5
70054
2
EC
- - 18.2
59671
2 - - 0.0
23102
2 - - 3.7
70279
2 - - 0.0
70605
2 - - 0.0
33121
2 - - 0.0
69357
2 - - 0.7
70694
2 - - 0.0
68955
2 - - 0.0
69135
2 - - 27.3
36109
2 - - 6.6
68964
2 - - 5.7
51103
2 - - 0.0
46862
2 - - 0.4
52407
2 - - 2.2
70229
2 - - 1.3
7152
Mtr10 AFU_orthologue AFUA_7G05970
2 - - 1.5
69769
2 - - 12.0
38262
2 - - 17.7
69013
2 - - 25.1
50459
2 - - 3.6
30317
2 - - 14.4
47347
2 - - 6.3
68428
2 - - 12.7
69178
2 - - 0.0
59142
2 - - 6.3
11326
2 - - 0.4
52342
2 - - 0.0
64690
2
EC
- - 4.6
38993
1 - - 0.0
69096
1 - - 0.0
49486
1 - - 0.0
46039
1 - - 0.0
43576
1 - - 0.0
68893
1 - - 0.0
50859
1 - - 0.0
8768
1
EC
- - 0.0
40781
1 - - 0.0
63070
1 - - 0.0
49504
1 - - 0.0
68735
1 - - 0.0
65137
1 - - 0.0
63089
1 - - 0.0
69598
1 - - 0.0
68445
1 - - 0.0
26334
1 - - 0.0
63901
1 - - 0.0
38959
1
EC
- - 0.0
69391
1 - - 0.0
69966
1 - - 0.0
69625
1 - - 0.0
69699
1 - - 0.0
57081
1 - - 0.0
69524
1 - - 0.0
21809
1 - - 0.0
69337
1 - - 0.0
33087
1 - - 0.0
69143
1 - -
61159
1 - - 0.0
51593
1 - - 0.0
17448
1
EC
- - 0.0
42294
1 - - 0.0
68856
1 - - 0.0
48824
1 - - 0.0
29387
1 - - 0.0
47873
1 - - 0.0
24952
1 - - 0.0
68475
1 - - 0.0
68853
1 - - 0.0
69114
1 - - 0.0
2675
1 - - 0.0
22900
Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p
1 - - 0.0
69879
1 - -
31061
1 - -
35627
1 - - 0.0
27180
1 - - 0.0
61995
1 - - 0.0