The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

ANTH domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ANTH domain

The AP180 N-terminal homology (ANTH) domain is a membrane binding domain found in endocytotic accessory proteins, such as AP180. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits. The ANTH domain is involved in phosphatidylinositol 4,5-bisphosphate (also known as PIP2) binding and is also responsible for membrane localisation of AP180. The ANTH domain containing proteins appear to be universal elements in nucleation of clathrin coats PMID:12740367,PMID:12742163.


GO Diversity

Unique GO annotations
137 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1334 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 13
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 8
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 26
Unique EC:
Unique GO: 137
Unique Species: 1334